Ruthenium-Catalyzed Regioselective Hydrohalogenation of Alkynes Mediated by Trimethylsilyl Triflate
- Bai, Yuye
- Lin, Zhenyuan
- Ye, Zhenying
- Dong, Dian
- Wang, Jing
- Chen, Lu
- Xie, Feng
- Li, Yibiao
- Dixneuf, Pierre H.
- Zhang, Min
Publication date
January 2022
DOI Publisher
American Chemical Society (ACS)Abstract
International audienceHere we describe a ruthenium-catalyzed regioselective hydrohaloge-nation reaction of alkynes under mild conditions. Commercially simple halogen sources such as KI, ZnBr2, and ZnCl2 were employed to achieve this transformation. Alkynes derived from bioactive molecules such as L-(-)-borneol, L-menthol, and estrone were also suitable for the transformation, demonstrating the potential synthetic value of this new reaction in organic synthesis
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