RATIONALE OF THE USE OF GLYCOPROTEIN Ά2 - GLOBULIN FRACTION FOR THE PREVENTION OF RECURRENCE OF CANCER OF THE UPPER RESPIRATORY TRACT

In Ukraine there is a steady increase in morbidity and mortality from cancer of the upper respiratory tract. The cancer process is accompanied by homeostasis disorders and purulent-septic postoperative complications associated with severe cancer and chemoradiation intoxication, which leads to the depletion of the antioxidant system, holding and enhancing the process of neoplastic immortalization, that is, the endless division of the cancer cell.Under such conditions, the protective mechanisms of the body require the active use of highly active antioxidants, which could provide a low concentration of aggressive free oxidative radicals due to neutralization.Purpose of the study: to evaluate the effect of the antioxidant glycoprotein ceruloplasmin on the indicators of exogenous and endogenous intoxication, as well as on clinical semiotics in the postoperative and relapse-free periods.Materials and methods: 75 male patients with laryngopharyngeal cancer aged 56 to 70 years were examined and operated on. According to the TNM system, patients werein II, III and IV stages of the disease and previously received a full course of radiation therapy. Patients of the 1st and 2nd groups received the accompanying therapy with biocerulin at all stages of treatment. In the control group, treatment was carried out without biocerulin.Results and Discussion: The reported results of a biochemical study of blood serum in patients with laryngopharyngeal cancer confirmed the presence of intoxication of varying degrees.Conclusions: studies have shown that the use of biocerulin for detoxification of patients led to the neutralization of aggressive free oxidative radicals, which made it possible to carry out surgical treatment without complications and to achieve an improvement in the quality of life of patients of the 1st and 2nd groups in comparison with the control group. The relapse-free period in patients of the 1st and 2nd groups was more than 5 years.Key words: Biocerulin (cerupoplasmin), pharynx, upper respiratory tract, laryngopharyngeal cancer, tonsils, surgical treatment, relapse-free period, quality of life