Plant-Based Vaccine for Livestock: Key Points to Unleash Platform Translation in Developing Countries

Purpose of reviewTen years ago the first plant-based vaccine was licensed (DowAgrosciences). It was only 20 years after the first report of a recombinant protein obtained through plant transformation technology. Back then, this vaccine was perceived as the first of an unlimited list of innovative products of a flourishing platform. Unexpectedly, since then, no other veterinary product based on plant molecular pharming (PMP) has reached the market. This review will reflect a trans-disciplinary view of the status and challenges that the molecular farming platform faces to become a strategic solution for the agroindustrial sector of developing countries.Recent findingsPlant-based veterinary vaccines (PBVV) have the potential to give answers to several challenges that animal health presents today. The urgent need to improve livestock productivity, especially in low and middle-income countries (LMIC), and the current concern about the emergence of antimicrobial resistance associated with animal production, demands new products such as inexpensive vaccines and therapeutics. Based on the translational research scheme, certain barriers that could have limited the development into products of many results obtained in the last 15 years were identified.SummaryUnquestionably, the development of innovation in LMIC is a key element in the feasibility of the platform. The emergence of PPP between multiple stakeholders as a strategy to overcome the existing disconnection between academia and industry, could enable the conversion of leading vaccine candidates from the stage of proof of concept into prototypes for industry, and thereby foster ?productization? in the field of veterinary vaccines.Fil: Pérez Aguirreburualde, María Sol. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Petruccelli, Silvana. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Bravo Almonacid, Fernando Felix. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Wigdorovitz, Andrés. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin