Helicobacter pylori and gastric autoimmunity
- D'Elios, Mario Milco
- Bergman, Mathijs P
- Amedei, Amedeo
- Appelmelk, Ben J
- Del Prete, Gianfranco
Publication date
January 2004
DOIAbstract
Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4(+) Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry. (C) 2004 Elsevier SAS. All rights reserved
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