Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group box 1 (HMGB1), a nuclear DNA-binding protein that activates innate immunity via the Toll-like receptor (TLR) 4, the receptor for advanced glycation end products (RAGE), and C-X-C chemokine receptor (CXCR) 4. This study investigated the phenotypes of murine bone-marrow-derived macrophages (BMDMs) stimulated with different HMGB1 redox isoforms using bulk RNA sequencing (RNA-Seq). Disulfide HMGB1 (dsHMGB1)-stimulated BMDMs showed a similar but distinct transcriptomic profile to LPS/IFNγ- and LPS-stimulated BMDMs. Fully redu...
Macrophages, key players in the innate immune system, showcase remarkable adaptability. Derived from...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
SIGNIFICANCE: High mobility group protein 1 (HMGB1) is an evolutionarily conserved and multi-functio...
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in respo...
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in respo...
Macrophage polarization is critical to inflammation and resolution of inflammation. We previously sh...
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in respo...
Macrophages are a heterogeneous cell population which in response to the cytokine milieu polarize in...
Macrophages are a heterogeneous cell population which in response to the cytokine milieu polarize in...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
OBJECTIVES: Decreased phagocytosis of apoptotic cells plays an important role in the pathogenesis of...
Background Macrophages are a heterogeneous cell population which in response to the cytokine milieu ...
The complex task of maintaining homeostasis and fighting diseases involves an intricate network of i...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
Macrophages, key players in the innate immune system, showcase remarkable adaptability. Derived from...
Macrophages, key players in the innate immune system, showcase remarkable adaptability. Derived from...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
SIGNIFICANCE: High mobility group protein 1 (HMGB1) is an evolutionarily conserved and multi-functio...
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in respo...
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in respo...
Macrophage polarization is critical to inflammation and resolution of inflammation. We previously sh...
Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in respo...
Macrophages are a heterogeneous cell population which in response to the cytokine milieu polarize in...
Macrophages are a heterogeneous cell population which in response to the cytokine milieu polarize in...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
OBJECTIVES: Decreased phagocytosis of apoptotic cells plays an important role in the pathogenesis of...
Background Macrophages are a heterogeneous cell population which in response to the cytokine milieu ...
The complex task of maintaining homeostasis and fighting diseases involves an intricate network of i...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
Macrophages, key players in the innate immune system, showcase remarkable adaptability. Derived from...
Macrophages, key players in the innate immune system, showcase remarkable adaptability. Derived from...
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage ...
SIGNIFICANCE: High mobility group protein 1 (HMGB1) is an evolutionarily conserved and multi-functio...