Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup
- Bruno, William
- Pastorino, Lorenza
- Ghiorzo, Paola
- Andreotti, Virginia
- Martinuzzi, Claudia
- Menin, Chiara
- Elefanti, Lisa
- Stagni, Camilla
- Vecchiato, Antonella
- Rodolfo, Monica
- Maurichi, Andrea
- Manoukian, Siranoush
- De Giorgi, Vincenzo
- Savarese, Imma
- Gensini, Francesca
- Borgognoni, Lorenzo
- Testori, Alessandro
- Spadola, Giuseppe
- Mandal\ue0, Mario
- Imberti, Gianlorenzo
- Savoia, Paola
- Astrua, Chiara
- Ronco, Anna Maria
- Farnetti, Alessandra
- Tibiletti, Maria Grazia
- Lombardo, Maurizio
- Palmieri, Giuseppe
- Ayala, Fabrizio
- Ascierto, Paolo
- Ghigliotti, Giovanni
- Muggianu, Marisa
- Spagnolo, Francesco
- Picasso, Virginia
- Tanda, Enrica Teresa
- Queirolo, Paola
- Bianchi Scarr\ue0, Giovanna
Publication date
January 2016
DOI Publisher
Elsevier BV ISSN
0190-9622 Citation count (estimate)
3Abstract
Multiple primary melanoma (MPM), in concert with a positive family history, is a predictor of cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) germline mutations. A rule regarding the presence of either 2 or 3 or more cancer events (melanoma and pancreatic cancer) in low or high melanoma incidence populations, respectively, has been established to select patients for genetic referral
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