Mutations in the RB1 locus leading to a loss of functional Rb protein cause intraocular tumors, which uniquely affect children worldwide. These tumors demonstrate rapid proliferation, which has recently been shown to be associated with an altered metabolic signature. We found that retinoblastoma tumors and in-vitro models lack Hexokinase 1 (HK1) and exhibit elevated fatty acid oxidation. We show that ectopic expression of RB1 induces HK1 protein in Rb null cells, and both RB1 and HK1 can mediate a metabolic switch from OXPHOS to glycolysis with increased pyruvate levels, reduced ATP production and reduced mitochondrial mass. Further, cells lacking Rb or HK1 can flexibly utilize glutamine and fatty acids to enhance oxidative phosphorylation-...
Retinoblastoma (Rb) is a rare type of pediatric eye cancer that rapidly develops from the immature c...
Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of ho...
Cancer is a redox disease. Low levels of reactive oxygen species (ROS) are beneficial for cells and ...
Mutations in the RB1 locus leading to a loss of functional Rb protein cause intraocular tumors, whic...
Lack of retinoblastoma (Rb) protein causes aggressive intraocular retinal tumors in children. Recent...
Retinoblastoma (Rb) is a pediatric intraocular malignancy that is proposed to originate from maturin...
Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biologi...
In a majority of cancer cells, inactivation of the retinoblastoma protein (pRB) through hyperphospho...
The tumor suppressor protein retinoblastoma (RB) is mechanistically linked to suppression of transcr...
Deficiency in the retinoblastoma protein (Rb) favors leanness and a healthy metabolic profile in mic...
INTRODUCTION The retina prefers to metabolize glucose through glycolysis rather than oxidative phos...
The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expre...
The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors...
Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancer...
Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier stud...
Retinoblastoma (Rb) is a rare type of pediatric eye cancer that rapidly develops from the immature c...
Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of ho...
Cancer is a redox disease. Low levels of reactive oxygen species (ROS) are beneficial for cells and ...
Mutations in the RB1 locus leading to a loss of functional Rb protein cause intraocular tumors, whic...
Lack of retinoblastoma (Rb) protein causes aggressive intraocular retinal tumors in children. Recent...
Retinoblastoma (Rb) is a pediatric intraocular malignancy that is proposed to originate from maturin...
Loss of the retinoblastoma (RB) tumor suppressor protein is a critical step in reprogramming biologi...
In a majority of cancer cells, inactivation of the retinoblastoma protein (pRB) through hyperphospho...
The tumor suppressor protein retinoblastoma (RB) is mechanistically linked to suppression of transcr...
Deficiency in the retinoblastoma protein (Rb) favors leanness and a healthy metabolic profile in mic...
INTRODUCTION The retina prefers to metabolize glucose through glycolysis rather than oxidative phos...
The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expre...
The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors...
Retinoblastoma (Rb) protein is a tumor suppressor that is dysregulated in a majority of human cancer...
Retinoblastoma is a malignant tumour of the retina which most often occurs in children. Earlier stud...
Retinoblastoma (Rb) is a rare type of pediatric eye cancer that rapidly develops from the immature c...
Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of ho...
Cancer is a redox disease. Low levels of reactive oxygen species (ROS) are beneficial for cells and ...