Dysregulation of sphingolipid metabolism plays a complex role in hematological malignancies, beginning with the first historical link between sphingolipids and apoptosis discovered in HL-60 leukemic cells. Numerous manuscripts have reviewed the field including the early discoveries that jumpstarted the studies. Many studies discussed here support a role for sphingolipids, such as ceramide, in combinatorial therapeutic regimens to enhance anti-leukemic effects and reduce resistance to standard therapies. Additionally, inhibitors of specific nodes of the sphingolipid pathway, such as sphingosine kinase inhibitors, significantly reduce leukemic cell survival in various types of leukemias. Acid ceramidase inhibitors have also shown promising re...
International audienceIt is well known that tumor formation arises from the imbalance between cell d...
AbstractSphingolipids are known to play important roles in the regulation of cell proliferation, res...
Drug resistance elicited by cancer cells still constitutes a huge problem that frequently impairs th...
Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular ...
Sphingolipids function as bioactive mediators of different cellular processes, mostly proliferation,...
Sphingolipids are sphingosine-based lipid molecules that have important functions in cellular signal...
AbstractSphingolipids function as bioactive mediators of different cellular processes, mostly prolif...
Conventional chemotherapy-based drug combinations have, until recently, been the backbone of most th...
The sphingolipids ceramide, sphingosine and sphingosine 1-phosphate have emerged as important signal...
International audienceChemotherapy is frequently used to treat primary or metastatic cancers, but in...
Sphingolipids are both structural molecules that are essential for cell architecture and second mess...
Sphingolipids, such as ceramide, sphingosine and sphingosine 1-phosphate (S1P) are bioactive molecul...
Sphingolipids, such as ceramide, sphingosine and sphingosine 1-phosphate (S1P) are bioactive molecul...
AbstractThrough modifications in the fine membrane structure, cell–cell or cell–matrix interactions,...
International audienceIt is well known that tumor formation arises from the imbalance between cell d...
AbstractSphingolipids are known to play important roles in the regulation of cell proliferation, res...
Drug resistance elicited by cancer cells still constitutes a huge problem that frequently impairs th...
Sphingolipids are major constituents of the cells with emerging roles in the regulation of cellular ...
Sphingolipids function as bioactive mediators of different cellular processes, mostly proliferation,...
Sphingolipids are sphingosine-based lipid molecules that have important functions in cellular signal...
AbstractSphingolipids function as bioactive mediators of different cellular processes, mostly prolif...
Conventional chemotherapy-based drug combinations have, until recently, been the backbone of most th...
The sphingolipids ceramide, sphingosine and sphingosine 1-phosphate have emerged as important signal...
International audienceChemotherapy is frequently used to treat primary or metastatic cancers, but in...
Sphingolipids are both structural molecules that are essential for cell architecture and second mess...
Sphingolipids, such as ceramide, sphingosine and sphingosine 1-phosphate (S1P) are bioactive molecul...
Sphingolipids, such as ceramide, sphingosine and sphingosine 1-phosphate (S1P) are bioactive molecul...
AbstractThrough modifications in the fine membrane structure, cell–cell or cell–matrix interactions,...
International audienceIt is well known that tumor formation arises from the imbalance between cell d...
AbstractSphingolipids are known to play important roles in the regulation of cell proliferation, res...
Drug resistance elicited by cancer cells still constitutes a huge problem that frequently impairs th...