Hit identification and biological evaluation of anticancer pyrazolopyrimidines endowed with anti-inflammatory activity
- S., Alcaro
- A., Artes
- M., Botta
- A., Zizzarri
- F., Orallo
- F., Ortuso
- Schenone, Silvia
- Brullo, Chiara
- M. Y., Cez
Publication date
January 2010
DOI Publisher
Wiley ISSN
1860-7179 Citation count (estimate)
12Abstract
A series of pyrazolopyrimidine derivs. was prepd., and their cyclo-oxygenase inhibitory activity was screened. It was found that these compds. demonstrated antiproliferative and anti-inflammatory activity. Among the synthetic compd., I revealed interesting COX-2 activity and selectivity
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