The diagnosis of acute kidney injury (AKI) traditionally depends on the serum creatinine (Scr) and urine output, which lack sufficient sensitivity and specificity. Using urinary exosomes as a biomarker has unique advantages. To assess whether urinary exosomal Na+/H+ exchanger isoform 3 (NHE3) protein could serve as a biomarker of AKI, we constructed four AKI rat models: cisplatin (7.5 mg/kg) injected intraperitoneally (IP), furosemide (20 mg/kg, IP) with a low-NaCl (0.03%) diet, a low-NaCl (0.03%) diet with candesartan (1 mg/kg, IP) and bilateral ischemia and reperfusion (I/R) injury for 40 min. Additionally, we assessed six sepsis-associated AKI patients and six healthy volunteers. Urinary exosomes were extracted by ultracentrifugation, an...
Acute kidney injury (AKI) is a common complication, impacting short- and long-term patient outcomes....
BackgroundAcute kidney injury (AKI) is a frequent complication of decompensated cirrhosis with incre...
Prerenal acute kidney injury (AKI) is thought to be a reversible loss of renal function without stru...
Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the u...
Abstract Background An early s...
Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellula...
Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically ava...
BackgroundUrine exosomes are small vesicles exocytosed into the urine by all renal epithelial cell t...
Acute kidney injury (AKI) is a common complication, impacting short- and long-term patient outcomes....
Early and reliable markers of acute kidney injury (AKI) are essential. One such candidate marker of ...
Vancomycin is commonly used as a first line therapy for gram positive organisms such as methicillin ...
Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Ti...
mRNA for biomarkers of kidney injury extracted from urinary exosomes may reflect or predict levels o...
A change in the serum creatinine is not sensitive for an early diagnosis of acute kidney injury. We ...
Background: mRNA for biomarkers of kidney injury extracted from urinary exosomes may reflect or pred...
Acute kidney injury (AKI) is a common complication, impacting short- and long-term patient outcomes....
BackgroundAcute kidney injury (AKI) is a frequent complication of decompensated cirrhosis with incre...
Prerenal acute kidney injury (AKI) is thought to be a reversible loss of renal function without stru...
Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the u...
Abstract Background An early s...
Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellula...
Acute kidney injury (AKI) is associated with increased mortality rate in patients but clinically ava...
BackgroundUrine exosomes are small vesicles exocytosed into the urine by all renal epithelial cell t...
Acute kidney injury (AKI) is a common complication, impacting short- and long-term patient outcomes....
Early and reliable markers of acute kidney injury (AKI) are essential. One such candidate marker of ...
Vancomycin is commonly used as a first line therapy for gram positive organisms such as methicillin ...
Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Ti...
mRNA for biomarkers of kidney injury extracted from urinary exosomes may reflect or predict levels o...
A change in the serum creatinine is not sensitive for an early diagnosis of acute kidney injury. We ...
Background: mRNA for biomarkers of kidney injury extracted from urinary exosomes may reflect or pred...
Acute kidney injury (AKI) is a common complication, impacting short- and long-term patient outcomes....
BackgroundAcute kidney injury (AKI) is a frequent complication of decompensated cirrhosis with incre...
Prerenal acute kidney injury (AKI) is thought to be a reversible loss of renal function without stru...