Significance Cardiovascular diseases remain the leading cause of death worldwide, with atherosclerosis being the most common source of clinical events. Metabolic changes with aging associate with concurrent increased risk of both type 2 diabetes and cardiovascular disease, with the former further raising the risk of the latter. The activity of a selective type of autophagy, chaperone-mediated autophagy (CMA), decreases with age or upon dietary excesses. Here we study whether reduced CMA activity increases risk of atherosclerosis in mouse models. We have identified that CMA is up-regulated early in response to proatherogenic challenges and demonstrate that reduced systemic CMA aggravates vascular pathology in these conditions. We also provid...
Abstract Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular ...
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However...
Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall and underlies the deve...
Significance Cardiovascular diseases remain the leading cause of death worldwide, with atheroscleros...
Atherosclerosis, the leading cause of cardiovascular death, is driven by hyperlipidemia, inflammatio...
Aim To investage the changes of autophagy in different stages of atherosclerosis (AS) in Apolipoprot...
SummaryWe investigated the role of autophagy in atherosclerosis. During plaque formation in mice, au...
We investigated the role of autophagy in atherosclerosis. During plaque formation in mice, autophagi...
International audienceIt has been known for some time that atherosclerotic lesions preferentially de...
We investigated the role of autophagy in atherosclerosis. During plaque formation in mice, autophagi...
<p>Macroautophagy/autophagy is considered as an evolutionarily conserved cellular catabolic process....
Abstract—Evidence is accumulating that autophagy occurs in advanced atherosclerotic plaques. Althoug...
Autophagy is a subcellular process that plays an important role in the degradation of proteins and d...
Autophagy dysfunction in mouse atherosclerosis models has been associated with increased lipid accum...
Abstract Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular ...
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However...
Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall and underlies the deve...
Significance Cardiovascular diseases remain the leading cause of death worldwide, with atheroscleros...
Atherosclerosis, the leading cause of cardiovascular death, is driven by hyperlipidemia, inflammatio...
Aim To investage the changes of autophagy in different stages of atherosclerosis (AS) in Apolipoprot...
SummaryWe investigated the role of autophagy in atherosclerosis. During plaque formation in mice, au...
We investigated the role of autophagy in atherosclerosis. During plaque formation in mice, autophagi...
International audienceIt has been known for some time that atherosclerotic lesions preferentially de...
We investigated the role of autophagy in atherosclerosis. During plaque formation in mice, autophagi...
<p>Macroautophagy/autophagy is considered as an evolutionarily conserved cellular catabolic process....
Abstract—Evidence is accumulating that autophagy occurs in advanced atherosclerotic plaques. Althoug...
Autophagy is a subcellular process that plays an important role in the degradation of proteins and d...
Autophagy dysfunction in mouse atherosclerosis models has been associated with increased lipid accum...
Abstract Athrosclerosis is conceived as a chronic inflammatory status affecting cells from vascular ...
Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial vessels. However...
Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall and underlies the deve...