BackgroundType I interferon (IFN) inhibits virus infection through multiple processes. Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the cellular metabolism. The sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1), as an interferon-stimulated gene (ISG), has been reported to inhibit a number of retroviruses and DNA viruses, by depleting dNTPs indispensable for viral DNA replication. Here we report a new antiviral activity of SAMHD1 against RNA viruses including HCV and some other flaviviruses infection.MethodsMultiple cellular and molecular biological technologies have been used to detect virus infection, replication and variation of intracellular proteins, includin...
SAMHD1 is a restriction factor for HIV-1 infection. . SAMHD1 mutations cause the autoinflammatory Ai...
SummarySAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammato...
SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammatory Aica...
BackgroundType I interferon (IFN) inhibits virus infection through multiple processes. Recent eviden...
Viruses exploit the host and induce drastic metabolic changes to ensure an optimal environment for r...
The enzyme, sterile α motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) diminis...
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+)...
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4+ T...
AbstractThe human SAMHD1 protein is a novel retroviral restriction factor expressed in myeloid cells...
Background: Type I interferon (IFN) treatment of some cells, including dendritic cells, macrophages ...
Interferons (IFNs) are essential anti-viral cytokines that suppress viral infections by upregulation...
International audienceBackgroundInterferon-α (IFN-α) is an essential mediator of the antiviral respo...
Abstract The InterFeron Induced TransMembrane (IFITM) proteins are interferon stimulated genes that ...
ABSTRACT Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection despit...
BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disea...
SAMHD1 is a restriction factor for HIV-1 infection. . SAMHD1 mutations cause the autoinflammatory Ai...
SummarySAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammato...
SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammatory Aica...
BackgroundType I interferon (IFN) inhibits virus infection through multiple processes. Recent eviden...
Viruses exploit the host and induce drastic metabolic changes to ensure an optimal environment for r...
The enzyme, sterile α motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) diminis...
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4(+)...
SAMHD1 restricts the replication of HIV-1 and other retroviruses in human myeloid and resting CD4+ T...
AbstractThe human SAMHD1 protein is a novel retroviral restriction factor expressed in myeloid cells...
Background: Type I interferon (IFN) treatment of some cells, including dendritic cells, macrophages ...
Interferons (IFNs) are essential anti-viral cytokines that suppress viral infections by upregulation...
International audienceBackgroundInterferon-α (IFN-α) is an essential mediator of the antiviral respo...
Abstract The InterFeron Induced TransMembrane (IFITM) proteins are interferon stimulated genes that ...
ABSTRACT Macrophages are susceptible to human immunodeficiency virus type 1 (HIV-1) infection despit...
BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disea...
SAMHD1 is a restriction factor for HIV-1 infection. . SAMHD1 mutations cause the autoinflammatory Ai...
SummarySAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammato...
SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the autoinflammatory Aica...