Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
- Abiega Etxabe, Oihane
- Beccari Galeano, Marlene Soledad
- Diaz-Aparicio, Irune
- Nadjar, Agnes
- Layé, Sophie
- Leyrolle, Quentin
- Gómez-Nicola, Diego
- Domercq García, María
- Pérez-Samartín, Alberto
- Sánchez-Zafra, Víctor
- Paris Guerrero, Ignacio
- Valero Gómez-Lobo, Jorge
- Savage, Julie C.
- Hui, Chin-Wai
- Tremblay, Marie-Ève
- Deudero, Juan J. P.
- Brewster, Amy L.
- Anderson, Anne E.
- Zaldumbide Dueñas, Laura
- Galbarriatu, Lara
- Marinas, Ainhoa
- Vivanco Ruiz, María del Mar
- Matute Almau, Carlos José
- Maletic-Savatic, Mirjana
- Encinas Pérez, Juan Manuel
- Sierra Saavedra, Amanda
Publication date
January 2016
DOI Publisher
Public Library of Science (PLoS) Journal
PLoS Biology Language
EnglishAbstract
Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients that drive phagocytosis, leading to the accumulation of apoptotic cells and inflammation
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