Advances in Click Chemistry for Single-Chain Nanoparticle Construction

Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.Financial support from the projects MAT2012-31088 (MINECO) and IT-654-13 (GV) is acknowledged. A. S.-S. thanks the PhD grant support of the Basque Government. I. P.-B. acknowledges CSIC for her JAE-PREDOC grant