[EN] Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might enhance neuroprotection. In demyelinating mouse lesions, local overexpression of semaphorin 3F (Sema3F), an oligodendrocyte progenitor cell (OPC) attractant, increases remyelination. However, molecular targeting to MS lesions is a challenge. A clinically relevant paradigm for delivering Sema3F to demyelinating lesions could be to use blood-derived macrophages as vehicles. Thus, we chose transplantation of genetically modified hematopoietic stem cells (HSCs) as means of obtaining chimeric mice with circulating Sem...
Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for regenerativ...
Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transiti...
Multiple Sclerosis (MS) is a chronic, autoimmune disease of the central nervous system (CNS), for wh...
International audiencePreventing neurodegeneration-associated disability progression inpatients with...
In the brain, axons are wrapped by myelin sheaths which ensure fast saltatory conduction of impulse...
Multiple Sclerosis (MS) is an inflammatory disease which causes areas of demyelination in the Centr...
AbstractMultiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell ...
AbstractMyelin is critical in maintaining electrical impulse conduction in the central nervous syste...
AbstractMultiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Conduction bloc...
Mobilization of remyelinating cells spontaneously occurs in the adult brain. These cellular resource...
: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent ax...
A novel proposal to find a cure for multiple sclerosis by genetically engineering neural stem cells ...
Failure of oligodendrocyteprecursor cell (OPC)differentiationhasbeen recognized asthe leading causef...
AbstractMyelin, a dielectric sheath that wraps large axons in the central and peripheral nervous sys...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for regenerativ...
Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transiti...
Multiple Sclerosis (MS) is a chronic, autoimmune disease of the central nervous system (CNS), for wh...
International audiencePreventing neurodegeneration-associated disability progression inpatients with...
In the brain, axons are wrapped by myelin sheaths which ensure fast saltatory conduction of impulse...
Multiple Sclerosis (MS) is an inflammatory disease which causes areas of demyelination in the Centr...
AbstractMultiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell ...
AbstractMyelin is critical in maintaining electrical impulse conduction in the central nervous syste...
AbstractMultiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Conduction bloc...
Mobilization of remyelinating cells spontaneously occurs in the adult brain. These cellular resource...
: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent ax...
A novel proposal to find a cure for multiple sclerosis by genetically engineering neural stem cells ...
Failure of oligodendrocyteprecursor cell (OPC)differentiationhasbeen recognized asthe leading causef...
AbstractMyelin, a dielectric sheath that wraps large axons in the central and peripheral nervous sys...
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS l...
Amongst neurological diseases, multiple sclerosis (MS) presents an attractive target for regenerativ...
Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transiti...
Multiple Sclerosis (MS) is a chronic, autoimmune disease of the central nervous system (CNS), for wh...