Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2\ua0years.

The aim of this study is to describe longitudinal changes in estimated glomerular filtration rate (eGFR) in a cohort of mother-to-child HIV-infected adolescents exposed to tenofovir dixoproxil fumarate (TDF) for at least 2 years. We retrospectively examined eGFR at starting TDF (T0), at 24 months (T2) and at the final assessment (T3). Twenty-nine patients were studied. The mean duration of TDF exposure was 67 months (24\u2013123). At baseline, the mean eGFR was 152 ml/min/1.73 m2 (105\u2013227, SD, 33). There was a significant decrease of eGFR from a mean of 152 ml/min/1.73 m2 (SD, 33) at T0 to 140 ml/min/1.73 m2 (SD, 33) at T2 and 123 ml/min/1.73 m2 (SD, 14) at T3. The decrease of eGFR was significant, with \u394GFR (T3-T0) of 1229 ml/min/1.73 m2 (SD, 30; p\u2009<\u20090.0001) and a mean \u394GFR per year of 126 and ml/min/1.73 m2 (SD, 8)