VPP: VERBASCOSIDE PENTA PROPIONATE, A NOVEL MULTIFUNCTIONAL INGREDIENT, DERIVING FROM TRADITIONAL REMEDIES INSPIRATION

The biological properties of verbascoside (V) comprise antioxidant, anti-inflammatory, photoprotective and chelating. The Plantago lanceolata is a perennial herbaceous plant spread throughout most of Europe and V is one of the most interesting components of the extracts and decoctions, that have a long history of use in traditional medicine. Starting from this finding we developed Buddleja davidii cell cultures, expressing very high concentrations of V to be used as a convenient source of the same. Moreover, in order to overcome low stability in biological medium we developed a prodrug (VPP), in order to make it more lipid-soluble. The parent as well as the synthesized compounds were evaluated for anti-oxidant activity by PCL assay (Photochemiluminescence) and for its stability in different solutions and formulations by HPLC. VPP and V were also evaluated on HaCaT cells by proliferation assays