An unusual association of hyperparathyroidism, ectopic GHRH secrection and bronchial carcinoid in a MEN1 family

E. Sala
E. Ferrante
E. Verrua
E. Malchiodi
F. Ermetici
M. Filopanti
S. Ferrero
M. C. Zatelli
E. degli Uberti
A. Spada
P. Beck-Peccoz
U. Verga

Publication date

January 2011

Publisher

Society for Endocrinology

Abstract

Introduction: MEN1 is characterized by tumors of parathyroid glands, pituitary and pancreas. Pituitary tumors frequently produce PRL and GH, but acromegaly due to ectopic GHRH secretion has been reported in <1% of cases. Here we present a case of two patients belonging to a MEN1 family (c.207delC; p.P69PfsX118 mutation (ENST00000377313), affected by primary hyperparathyroidism, in association with acromegaly due to ectopic GHRH secretion and bronchial carcinoid, respectively. Case report: A 18-year-old boy came to our observation with clinical, biochemical findings and scintigraphic image diagnostic of primary hyperparathyroidism. He successfully underwent subtotal parathyroidectomy. Given the young age and the presence of multiple parathy...

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An unusual association of hyperparathyroidism, ectopic GHRH secrection and bronchial carcinoid in a MEN1 family

Abstract

Extracted data

An unusual association of hyperparathyroidism, ectopic GHRH secrection and bronchial carcinoid in a MEN1 family

Abstract

Extracted data

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