Abstract We have exposed mouse thymocytes and P-815 mastocytoma cells to four different conditions reported to cause apoptosis: 1) incubation in the absence of mitogenic factors; 2) incubation in the presence of dexamethasone; 3) stimulation with external ATP; 4) treatment with high concentrations of the K+ ionophore valinomycin. These treatments caused DNA fragmentation to a varying extent in the two cell types. High stringency hybridization with a cDNA probe specific to a mitochondrial DNA sequence revealed that during apoptosis induced by lack of mitogenic factors, dexamethasone, or extracellular ATP, mitochondrial DNA was not fragmented. On the contrary, valinomycin caused extensive degradation of mitochondrial DNA. These results suppo...
AbstractApoptosis of human B cells and murine T and B cells was analyzed by DNA agarose gel electrop...
It has been shown recently that apoptotic degradation of genomic DNA in mammalian cells starts by ex...
Apoptosis is vital in maintaining homeostasis, and its deregulation can have dire pathological conse...
Abstract We have exposed mouse thymocytes and P-815 mastocytoma cells to four different conditions ...
Apoptosis is the predominant form of cell death observed in a variety of physiological and pathologi...
AbstractWe have studied the role of changes in mitochondrial membrane potential (ΔΨ) in two widely-u...
One of the hallmarks of apoptosis is the digestion of genomic DNA by an endonuclease, generating a l...
We have studied the role of changes in mitochondrial membrane potential (Delta Psi) in two widely-us...
Apoptosis is an active type of cell death, occurring under several physiological and pathological co...
We isolated and purified mitochondria from mouse livers and spinach leaves. When added into egg extr...
DNA fragmentation during apoptosis is characterized by endonucleolytic cleavage of chromosomal DNA i...
We have attempted to determine whether loss of mtDNA and respiratory chain function result in apopto...
Apoptosis is a well studied mechanism of controllable cell death, implicated in various disease stat...
In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and t...
Apoptosis has long been recognised by two hallmarks of the end stage of nuclear breakdown: collapse ...
AbstractApoptosis of human B cells and murine T and B cells was analyzed by DNA agarose gel electrop...
It has been shown recently that apoptotic degradation of genomic DNA in mammalian cells starts by ex...
Apoptosis is vital in maintaining homeostasis, and its deregulation can have dire pathological conse...
Abstract We have exposed mouse thymocytes and P-815 mastocytoma cells to four different conditions ...
Apoptosis is the predominant form of cell death observed in a variety of physiological and pathologi...
AbstractWe have studied the role of changes in mitochondrial membrane potential (ΔΨ) in two widely-u...
One of the hallmarks of apoptosis is the digestion of genomic DNA by an endonuclease, generating a l...
We have studied the role of changes in mitochondrial membrane potential (Delta Psi) in two widely-us...
Apoptosis is an active type of cell death, occurring under several physiological and pathological co...
We isolated and purified mitochondria from mouse livers and spinach leaves. When added into egg extr...
DNA fragmentation during apoptosis is characterized by endonucleolytic cleavage of chromosomal DNA i...
We have attempted to determine whether loss of mtDNA and respiratory chain function result in apopto...
Apoptosis is a well studied mechanism of controllable cell death, implicated in various disease stat...
In this paper the specific mitochondrial respiratory chain inhibitors rotenone and antimycin A and t...
Apoptosis has long been recognised by two hallmarks of the end stage of nuclear breakdown: collapse ...
AbstractApoptosis of human B cells and murine T and B cells was analyzed by DNA agarose gel electrop...
It has been shown recently that apoptotic degradation of genomic DNA in mammalian cells starts by ex...
Apoptosis is vital in maintaining homeostasis, and its deregulation can have dire pathological conse...