Do we need a novel approach to the research and development of ingredients used for a customized treatment of photo-induced oxidative stress?

Cosmetogenomic is a branch of welfare science that studies the interaction between the genetic identity of an individual and his response to cosmetic treatments. It is widely documented that the bio-mechanical properties of skin are influenced by physiological processes and environmental agents that alter the structure. The aging process is directly related to the formation of free radicals, which accumulate in response to normal biochemical processes and environmental insults, including UV exposure. The main effect of UV exposure is the increase of the accumulation of mutations in nuclear and mitochondrial DNA. Mutations of mitochondrial DNA (mtDNA) have been extensively studied and it’s clear their correlation with the process of photoaging of the skin and many degenerative diseases. Many studies have shown that the susceptibility to UV-induced damage is different in each person suggesting that preventive treatment can be customized on the base of individual genetic characteristics. We have then decide to developed a new method (GENIAC) for the selection and evaluation of ingredients and formulations truly innovative and effective against DNA damage linked to free radicals