Body fat distribution may influence both lipidemic and oxidative profiles in women. Results of Cross-sectional study

Visceral-abdominal adiposity, a widely recognized cardiovascular disease (CVD) risk factor, is frequently associated with atherogenic dyslipidemia (1). The Reactive Oxygen Species (ROS)-mediated oxidative modification of LDL cholesterol is implicated in the etiopathogenesis of several forms of CVD. We evaluated the interrelationships among Body Fat Distribution assessed by Dual Energy X-Ray absorptiometry (DXA), oxidant (hydroperoxides) and antioxidant (total antioxidants, Uric Acid and Thiols) markers and lipidic profile (Total, LDL and HDL cholesterol, Tryglicerides): This cross-sectional study was based on a sample of 132 healthy women. We found significant correlations between abdominal fat and LDL cholesterol (r = 0.300, p<0.05), LDL/HDL ratio (r = 0.339, p<0.001), tryglicerides (r = 0.267, p<0.001) and HDL cholesterol (r = -0.199, p<0.05). Total and abdominal fat, were significantly correlated with total antioxidants (r = 0.257, p<0.01 and 0.259, p<0.01 respectively) due to the essential contribute of Uric Acid, the highest concentrated endogen antioxidants of human organism, which is mostly associated with fat stored in abdomen (r= 0.371, p<0.001). Hydroperoxides only showed a positive correlation with fat localized on legs (r = 0.226, p