Add to ORKGThe short arm of chromosome 1 is frequently affected by rearrangements in a variety of human malignancies. Genetic alterations, predominantly deletions, which are indicative of the presence of a putative tumor suppressor gene at chromosome 1p, are observed in breast cancer. In order to define the altered locus, eleven highly polymorphic microsatellite markers on chromosome 1p were used to detect loss of heterozygosity. We analyzed 52 cases of breast cancer and found 4 common deleted regions at chromosome 1p. Twenty-two of 52 (42%) informative patients showed at least 1 affected locus. The region most frequently exhibiting loss of heterozygosity was 1p31 (11/39; 28%); the other three common deleted regions were 1p36 (10/44; 23%), 1p35-36 (5/...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Cytogenetic and molecular analyses of colorectal cancer cells have revealed deletions at 1p as promi...
Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who we...
A flow-sorted chromosome 1 cosmid library was used to produce a cosmid pocket map spanning two regio...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
Genetic alterations such as deletions, amplifications, and translocations occurring on human chromos...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
232 human primary invasive breast tumors were analyzed with 13 polymorphic microsatellite markers sp...
The distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 huma...
Chromosome 11 is frequently altered in several types of human neoplasms. In breast cancer, loss of h...
Studies of loss of heterozygosity (LOH) in breast tumor DNA suggest that several tumor suppressor ge...
In breast cancer, loss of heterozygosity (LOH) has been described on the long arm of chromosome 7 at...
DNA fingerprinting by arbitrarily primed PCR (AP-PCR) was employed to identify molecular genetic alt...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Cytogenetic and molecular analyses of colorectal cancer cells have revealed deletions at 1p as promi...
Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who we...
A flow-sorted chromosome 1 cosmid library was used to produce a cosmid pocket map spanning two regio...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
Genetic alterations such as deletions, amplifications, and translocations occurring on human chromos...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
232 human primary invasive breast tumors were analyzed with 13 polymorphic microsatellite markers sp...
The distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 huma...
Chromosome 11 is frequently altered in several types of human neoplasms. In breast cancer, loss of h...
Studies of loss of heterozygosity (LOH) in breast tumor DNA suggest that several tumor suppressor ge...
In breast cancer, loss of heterozygosity (LOH) has been described on the long arm of chromosome 7 at...
DNA fingerprinting by arbitrarily primed PCR (AP-PCR) was employed to identify molecular genetic alt...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Cytogenetic and molecular analyses of colorectal cancer cells have revealed deletions at 1p as promi...
Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who we...