Labeling and biodistribution studies of Tc-99m radiopharmaceuticals with (o-hydroxyphenyl)diphenylphosphine

New Tc-99m radiopharmaceuticals with the ligand (o-hydroxyphenyl)diphenylphosphine have been prepared and their biodistributions evaluated in rats. The monoxo Tc(V) complex [99mTc(0)Cl(PO),J, the Tc(IV) complex [99mTc(OH),(PO),], the Tc(IJI) complex [99mTc(PO),], and the nitrido Tc(V) complex [99”Tc(N)(PO),] have been characterized by TLC and HPLC chromatography, and their chemical structure elucidated by comparison with the corresponding complexes obtained using the P-emitting isotope Tc-99g. Biodistribution studies of these complexes have been carried out in rats