Add to ORKGThe existence of a nuclear polyphosphoinositol metabolism independent from that at the plasma membrane is now widely recognized. Specific changes in the nuclear phosphatidylinositol (Ptdlns) metabolism have been implicated in cell growth, differentiation, and neoplastic transformation. Here we shall review the main features of nuclear inositol lipid signaling through type I IGF receptor, focusing the attention on the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, given its peculiar localization in the nuclear compartment
Lipid signalling molecules are essential components of the processes that allow one extracellular si...
Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which mo...
The nuclear inositol lipid cycle is a well known process, and nuclear phosphoinositide-specific phos...
none7The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma ...
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled ...
Over the last years, evidence has suggested that phosphoinositides, which are involved in the regula...
Evidence accumulated over the past 20 years has highlighted the presence of an autonomous nuclear in...
The existence of phospholipids in chromosomes has been suggested by the work of La Cour et al. (1958...
Inositol lipids are key regulators of several cellular functions. The identification of an independe...
Strong evidence has been obtained during the last 16 years suggesting that phosphoinositides, which ...
Inositol lipids originally shown to be metabolized in the cytosol have been detected also in the nuc...
The existence of an independent nuclear inositide pathway distinct from the cytoplasmic one has been...
The involvement of phospholipids and in particular polyphosphoinositides in cellular signalling has ...
It has been recently shown that also the nucleus is a site for both synthesis and hydrolysis of the ...
The nucleus was shown to be a site for inositol lipid cycle which can be affected by treatment of qu...
Lipid signalling molecules are essential components of the processes that allow one extracellular si...
Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which mo...
The nuclear inositol lipid cycle is a well known process, and nuclear phosphoinositide-specific phos...
none7The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma ...
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled ...
Over the last years, evidence has suggested that phosphoinositides, which are involved in the regula...
Evidence accumulated over the past 20 years has highlighted the presence of an autonomous nuclear in...
The existence of phospholipids in chromosomes has been suggested by the work of La Cour et al. (1958...
Inositol lipids are key regulators of several cellular functions. The identification of an independe...
Strong evidence has been obtained during the last 16 years suggesting that phosphoinositides, which ...
Inositol lipids originally shown to be metabolized in the cytosol have been detected also in the nuc...
The existence of an independent nuclear inositide pathway distinct from the cytoplasmic one has been...
The involvement of phospholipids and in particular polyphosphoinositides in cellular signalling has ...
It has been recently shown that also the nucleus is a site for both synthesis and hydrolysis of the ...
The nucleus was shown to be a site for inositol lipid cycle which can be affected by treatment of qu...
Lipid signalling molecules are essential components of the processes that allow one extracellular si...
Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which mo...
The nuclear inositol lipid cycle is a well known process, and nuclear phosphoinositide-specific phos...