1. Reperfusion of rabbit isolated hearts after 60 min of ischaemia resulted in poor recovery of mechanical function, release of creatine phosphokinase (CPK) and of reduced (GSH) and oxidized (GSSG) glutathione, reduction of mitochondrial superoxide dismutase (Mn SOD) activity and of tissue GSH/GSSG ratio with a shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. 2. Pretreatment of the isolated heart with the stable prostacyclin analogue (iloprost) at 27 or 270 nM, but not at 2.7 nM, improved the functional recovery of the myocardium, reduced CPK, GSH and GSSG release, maintained Mn SOD activity and attenuated the occurrence of oxidative stress. 3. This effect of iloprost cannot be explained b...
1. The effects of treatment with a number of cyclo-oxygenase inhibitors, (celecoxib, meloxicam, DuP-...
BACKGROUND: We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-r...
This study investigates the effects of cardiac ischemic preconditioning and iloprost on reperfusion ...
To assess whether the administration of the stable prostacyclin-mimetic ZK 36374 (iloprost) protects...
It is known that myocardial ischaemia causes a marked decline of cellular thiol pool and of protein ...
This study was designed to assess the influence of St. Thomas Hospital cardioplegic solution (St. Th...
OBJECTIVE: The aim of this study was to evaluate antioxidant and cytoprotective effects of iloprost ...
Oxygen radical generation induced by postischemic reperfusion can overwhelm endogenous radical scave...
The effect of the prostacyclin-mimetic, iloprost, on the reversibly damaged ("stunned") my...
In this study we attempted to determine whether administration of iloprost (ZK 36374), a chemically ...
In the isolated and perfused rabbit heart ischemia induced a rapid decline of contractility, associa...
A growing body of evidence has now accumulated supporting the involvement of oxygen-derived free rad...
Perfusion of the isolated rabbit heart with 5 x 10 6 human polymorphonuclear ...
There is evidence that oxygen-derived free radicals may play a role in myocardial ischaemic and repe...
1. The effects of treatment with a number of cyclo-oxygenase inhibitors, (celecoxib, meloxicam, DuP-...
1. The effects of treatment with a number of cyclo-oxygenase inhibitors, (celecoxib, meloxicam, DuP-...
BACKGROUND: We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-r...
This study investigates the effects of cardiac ischemic preconditioning and iloprost on reperfusion ...
To assess whether the administration of the stable prostacyclin-mimetic ZK 36374 (iloprost) protects...
It is known that myocardial ischaemia causes a marked decline of cellular thiol pool and of protein ...
This study was designed to assess the influence of St. Thomas Hospital cardioplegic solution (St. Th...
OBJECTIVE: The aim of this study was to evaluate antioxidant and cytoprotective effects of iloprost ...
Oxygen radical generation induced by postischemic reperfusion can overwhelm endogenous radical scave...
The effect of the prostacyclin-mimetic, iloprost, on the reversibly damaged ("stunned") my...
In this study we attempted to determine whether administration of iloprost (ZK 36374), a chemically ...
In the isolated and perfused rabbit heart ischemia induced a rapid decline of contractility, associa...
A growing body of evidence has now accumulated supporting the involvement of oxygen-derived free rad...
Perfusion of the isolated rabbit heart with 5 x 10 6 human polymorphonuclear ...
There is evidence that oxygen-derived free radicals may play a role in myocardial ischaemic and repe...
1. The effects of treatment with a number of cyclo-oxygenase inhibitors, (celecoxib, meloxicam, DuP-...
1. The effects of treatment with a number of cyclo-oxygenase inhibitors, (celecoxib, meloxicam, DuP-...
BACKGROUND: We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-r...
This study investigates the effects of cardiac ischemic preconditioning and iloprost on reperfusion ...