Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol.

Aim: To investigate whether dorzolamide modifies peri-papillary retinal hemodynamics in juvenile primary open-angle glaucoma (JPOAG) patients treated with timolol. Methods: In 40 JPOAG subjects, before and after dorzolamide co-administration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field, retinal flowmetry. Results: Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction (1.75 mmHg, with a 95% CI of 1.23 to 2.26; p < 0.05), OPP increase (5.09 mmHg, with a 95% CI of 2.97 to 7.20; p < 0.02), and retinal blood flow improvement (35.0 arbitrary units, with a 95% CI of 12.20 to 57.80; p < 0.03). BP, HR, and visual field indices did not change. Conclusions: Dorzolamide, in association or in fixed-combination with timolol, significantly improves retinal blood flow in JPOAG patients