A series of novel pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine substituted at N-8 pyrazole nitrogen and at the 5-amino group was synthesized and their affinities to all four cloned human adenosine receptor subtypes were evaluated by competition binding assays using [H-3]-DPCPX (A(1) and A(2B)), [H-3]-SCH 58261 (A(2A)), and [H-3]-MRE3008-F20 (A(3)) as radioligands. In particular, the structural requirements necessary for adenosine A2B receptor recognition were investigated. These preliminary results confirm that the free amino group at the 5-position confers better A(2B) affinity, while the effect of the chain at nitrogen pyrazole nucleus, the 8-position, seems to be preferred with respect to the corresponding N-7 regioisomers. The introdu...
[1,2,4]Triazolo[1,5-c]pyrimidine is a promising platform to develop adenosine receptor antagonists. ...
Some pyrazolotriazolopyrimidines bearing different heteroarylcarbamoylamino moieties at the N5-posit...
In the last few years the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) scaffold was investi...
A new series of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines bearing various substituents at bot...
A new series of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines bearing various substituents at bot...
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
Adenosine receptors are largely distributed in our organism and are promising therapeutic targets fo...
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
Adenosine, a widely distributed modulator, regulates many physiological functions through specific c...
In the present study, a molecular simplification approach was employed to design novel bicyclic pyra...
An efficient synthetic procedure was adopted to synthesize a series of new molecules containing the ...
In the past few decades, medicinal chemistry research towards potent and selective antagonists of hu...
Adenosine was defined as a neuromodulator which exerts its action by interaction with specific G-pro...
A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed...
A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed...
[1,2,4]Triazolo[1,5-c]pyrimidine is a promising platform to develop adenosine receptor antagonists. ...
Some pyrazolotriazolopyrimidines bearing different heteroarylcarbamoylamino moieties at the N5-posit...
In the last few years the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) scaffold was investi...
A new series of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines bearing various substituents at bot...
A new series of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines bearing various substituents at bot...
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
Adenosine receptors are largely distributed in our organism and are promising therapeutic targets fo...
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
Adenosine, a widely distributed modulator, regulates many physiological functions through specific c...
In the present study, a molecular simplification approach was employed to design novel bicyclic pyra...
An efficient synthetic procedure was adopted to synthesize a series of new molecules containing the ...
In the past few decades, medicinal chemistry research towards potent and selective antagonists of hu...
Adenosine was defined as a neuromodulator which exerts its action by interaction with specific G-pro...
A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed...
A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed...
[1,2,4]Triazolo[1,5-c]pyrimidine is a promising platform to develop adenosine receptor antagonists. ...
Some pyrazolotriazolopyrimidines bearing different heteroarylcarbamoylamino moieties at the N5-posit...
In the last few years the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) scaffold was investi...