The effects of androgen and estrogen on cell growth and gene expression were investigated in KJ29 kidney epithelial cells. Incorporation of 3H leucine and 3H thymidine was increased by androgen at 10nM, but not by estrogen. Estrogen however, inhibited the effects induced by androgen. In addition, cell number and the proliferation marker Ki67 were increased by androgen, but not by estrogen. Levels of androgen receptor RNA, as detected by RT-PCR and Northern blot analysis, were not affected by either androgen or estrogen. Levels of estrogen receptor RNA could be detected only by RT-PCR, and disappeared after estrogen treatment. These studies show that sex steroid receptors are differently expressed in KJ29 cells, and suggest that androgen, vi...
To explore the ability of androgens to affect gene expression in Sertoli and peritubular cells in vi...
The actions of androgens are mediated through an androgen receptor (AR), and AR activity is modulate...
Androgens have important effects on the human skeleton, and deficiency has been associated with bone...
Studies on hormonal action frequently focus on a single hormone. In intact animals, however, genes ...
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone rece...
textabstractThe effects of androgens, antiandrogens, and other steroid hormones on growth of the hum...
Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and accounts f...
Although the androgen receptor (AR) has been detected by ligand-binding assays, there is little know...
markdownabstractAbstract LNCaP cells (derived from a lymph node carcinoma of the human prostate) ...
Although the majority of primary human breast cancers express the androgen receptor (AR), the role o...
Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and accounts f...
Androgen regulation of androgen receptor (AR) expression has been observed in a variety of tissues, ...
textabstractIn whole cells, the effects of several androgens and antiandrogens on the in t...
textabstractAbstract LNCaP tumor cells, derived from a metastatic lesion of a human prostatic carci...
<span style="line-height: 115%; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-fareast...
To explore the ability of androgens to affect gene expression in Sertoli and peritubular cells in vi...
The actions of androgens are mediated through an androgen receptor (AR), and AR activity is modulate...
Androgens have important effects on the human skeleton, and deficiency has been associated with bone...
Studies on hormonal action frequently focus on a single hormone. In intact animals, however, genes ...
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone rece...
textabstractThe effects of androgens, antiandrogens, and other steroid hormones on growth of the hum...
Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and accounts f...
Although the androgen receptor (AR) has been detected by ligand-binding assays, there is little know...
markdownabstractAbstract LNCaP cells (derived from a lymph node carcinoma of the human prostate) ...
Although the majority of primary human breast cancers express the androgen receptor (AR), the role o...
Renal cell carcinoma (RCC) originates in the lining of the proximal convoluted tubule and accounts f...
Androgen regulation of androgen receptor (AR) expression has been observed in a variety of tissues, ...
textabstractIn whole cells, the effects of several androgens and antiandrogens on the in t...
textabstractAbstract LNCaP tumor cells, derived from a metastatic lesion of a human prostatic carci...
<span style="line-height: 115%; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-fareast...
To explore the ability of androgens to affect gene expression in Sertoli and peritubular cells in vi...
The actions of androgens are mediated through an androgen receptor (AR), and AR activity is modulate...
Androgens have important effects on the human skeleton, and deficiency has been associated with bone...