Visceromotor responses to calcitonin gene-related peptide (CGRP) in the rat lower urinary tract: evidence for a transmitter role in the capsaicin-sensitive nerves of the ureter.
- MAGGI CA
- GIULIANI S
- SANTICIOLI P
- L. ABELLI
- MELI A.
Publication date
January 1987
DOI Publisher
Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598 ISSN
0014-2999 Citation count (estimate)
68Abstract
Little effects of CGRP were recorded on urinary bladder motility or plasma extravation. Otherwise, CGRP inhibited motility of isolated rat proxinal urethra and ureters and counteracted the contractile response to neurokinins. Edivence is provided that CGRP is able to influence the motility of the rat lower urinary tract, but exhibits marked regional differences. Endogenous CGRP could be the the inhibitory neurotransmitter which, when released from capsaicin-sensitive fibres, participate in the control of ureteral motility
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