Several examples support the concept that modest chemical modifications can drastically alter the biological profile of the compounds both regard to different receptor systems and inside the same system, leading to unexpected and interesting results. This consideration has prompted Boström et al. to question whether structurally similar ligands bind in a similar fashion.1 In a recent study about new 6,6-diphenyl-1,4-dioxane derivatives, we demonstrated that small modifications on the 2-phenoxyethyl moiety induced significant biological changes. In fact, the unsubstituted 1, the 2-methoxy 2, and the 2,6-dimethoxy 3 analogues proved to be endowed with high cytotossic effect, α1D-adrenergic receptor (α1D-AR) antagonist and 5-HT1A receptor full...
Novel 1,4-dioxane compounds structurally related to WB 4101 (1) were prepared in order to investigat...
In an effort to explore the spatial limits of the pendent phenyl accessory binding domain, a series ...
WB 4101-related benzodioxans 3-9 were synthesized, and their biological profiles at alpha1-adrenorec...
Several examples support the concept that modest chemical modifications can drastically alter the bi...
5-HT1A receptor and α1-adrenoreceptor (α1-AR) binding sites recognized by the 1,4-dioxanes 2−4 displ...
5-HT<sub>1A</sub> receptor and α<sub>1</sub>-adrenoreceptor (α<sub>1</sub>-AR) binding sites recogni...
The quite planar 1,4-benzodioxane structure of the non-subtype selective α1-adrenergic antagonist WB...
A series of derivatives obtained by moving the aromatic moiety on the 1,4-dioxane ring of compounds ...
Our previous structure-affinity relationship study had considered the enantiomers of the naphthodiox...
In this paper, the enantiomers of (±)-1, previously studied as α1 and 5-HT1A ligands, were prepared ...
A series of derivatives obtained by moving the aromatic moiety on the 1,4-dioxane ring of compounds ...
The analogues 2-5 of the potent 5-HT1A receptor agonist and α1d-adrenoceptor (α1d-AR) antagonist 1 ...
Novel 1,4-dioxane compounds structurally related to WB 4101 (1) were prepared in order to investigat...
A number of enantiomeric pairs of naphthodioxane, tetrahydronaphthodioxane and naphthoxy analogues o...
A strategy that can lead to the discovery of novel biologically active compounds, and over the last ...
Novel 1,4-dioxane compounds structurally related to WB 4101 (1) were prepared in order to investigat...
In an effort to explore the spatial limits of the pendent phenyl accessory binding domain, a series ...
WB 4101-related benzodioxans 3-9 were synthesized, and their biological profiles at alpha1-adrenorec...
Several examples support the concept that modest chemical modifications can drastically alter the bi...
5-HT1A receptor and α1-adrenoreceptor (α1-AR) binding sites recognized by the 1,4-dioxanes 2−4 displ...
5-HT<sub>1A</sub> receptor and α<sub>1</sub>-adrenoreceptor (α<sub>1</sub>-AR) binding sites recogni...
The quite planar 1,4-benzodioxane structure of the non-subtype selective α1-adrenergic antagonist WB...
A series of derivatives obtained by moving the aromatic moiety on the 1,4-dioxane ring of compounds ...
Our previous structure-affinity relationship study had considered the enantiomers of the naphthodiox...
In this paper, the enantiomers of (±)-1, previously studied as α1 and 5-HT1A ligands, were prepared ...
A series of derivatives obtained by moving the aromatic moiety on the 1,4-dioxane ring of compounds ...
The analogues 2-5 of the potent 5-HT1A receptor agonist and α1d-adrenoceptor (α1d-AR) antagonist 1 ...
Novel 1,4-dioxane compounds structurally related to WB 4101 (1) were prepared in order to investigat...
A number of enantiomeric pairs of naphthodioxane, tetrahydronaphthodioxane and naphthoxy analogues o...
A strategy that can lead to the discovery of novel biologically active compounds, and over the last ...
Novel 1,4-dioxane compounds structurally related to WB 4101 (1) were prepared in order to investigat...
In an effort to explore the spatial limits of the pendent phenyl accessory binding domain, a series ...
WB 4101-related benzodioxans 3-9 were synthesized, and their biological profiles at alpha1-adrenorec...