Inclusion of vitamin D2 in ß-cyclodextrin. Evaluation of different complexation methods
- Giovanni Filippo Palmieri
- Pascal Wehrlè
- Andrè Stamm
DOIAbstract
Evaluation of inclusion complexation of vitamin D2 with β-cyclodextrin in aqueous solution and solid state was performed by Phase Solubility Diagramm, HPLC, DSC, X-RAY Diffractometry, NMR. Solid inclusion complexes were prepared by spray-drying, kneading and solid dispersion. The dissolution profiles of the complex either in powder or in tablets were studied in order to select the best inclusion process
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