Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390

Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity

BOLOGNESE A.
CORREALE G.
MANFRA M.
LAVECCHIA, ANTONIO
NOVELLINO, ETTORE
PEPE S.

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5H-ben...

D-ring modified paclitaxel analogues and approaches towards 1,7-dideoxypaclitaxel analogues from taxine

Beusker, P.H.

January 2002

Paclitaxel (Taxol©) is one of the most effective anticancer agents known to man to date. It acts by ...

Antitumor Agents. 5. Synthesis, structure−activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity.

A.Bolognese
G.Correale
M.Manfra
A.La Vecchia
E.Novellino
S.Pepe.

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1−6), tetrahydro-5H-ben...

Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390

BARBONI, Luciano
BALLINI, Roberto
GIARLO, Guido
APPENDINO G.
FONTANA G.
BOMBARDELLI E.

January 2005

Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer g...

14Beta-Hydroxy-10-deacetylbaccatin III as a Convenient, Alternative Substrate for the Improved Synthesis of Methoxylated Second-Generation Taxanes

BARBONI, Luciano
GIARLO, Guido
BALLINI, Roberto
FONTANA G.

January 2006

This article describes a new, convenient, improved synthesis of the 2-debenzoyl-2-m-methoxybenzoyl-7...

Design, Synthesis and Biological Evaluation of New Generation

January 2016

Novel second-generation taxoids with systematic modifications at the C2, C10, and C3’N positions wer...

‘Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J’

BOTTA, MAURIZIO
S. ARMAROLI
D. CASTAGNOLO
G. FONTANA
P. PERA
E. BOMBARDELLI

January 2007

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro f...

SYNTHESIS AND MOLECULAR MODELING OF TAXANES MODIFIED AT RING-C

MENICHINCHERI M
CECCARELLI W
CIOMEI M
DANELLO M
FUSARBASSINI D
MONGELLI N
PESENTI E
PINCIROLI V
VANOTTI E.
BOTTA, MAURIZIO
CORELLI, FEDERICO
TAFI, ANDREA

January 1995

Some new paclitaxel analogs, modified at ring C, - namely the 7-alpha-mesylate, 7-deoxy-7-alpha-amin...

Synthesis and biological evaluation of novel taxane terpenoids

Gasiorowski, Stephanie
Tischler, Jessica L.
Zand, Ali R.

March 2004

Paclitaxel, a diterpene natural product from the Pacific Yew tree, Taxus brevifolia, has emerged as ...

Overcoming tumor drug resistance with high-affinity taxanes: A SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines

Yang, Chun-Gang
Barasoain, Isabel
Li, Xuan
Matesanz, Ruth
Liu, Ronghua
Sharom, Frances J.
Yin, Da-Li
Díaz, José Fernando
Fang, Wei-Shuo

October 2021

A series of C2-modified 10-deacetyl-7-propionyl cephalomannine derivatives was designed, prepared, a...

Antitumor Activity of Substituted E-3-(3,4,5-Trimethoxybenzylidene)-1,3-dihydroindol-2-ones

ANDREANI, ALDO
BURNELLI, SILVIA
GRANAIOLA, MASSIMILIANO
LEONI, ALBERTO
LOCATELLI, ALESSANDRA
MORIGI, RITA
RAMBALDI, MIRELLA
VAROLI, LUCILLA
M. W. Kunkel

January 2006

The design and synthesis of anticancer E-3-(3,4,5-trimethoxybenzilidene)-1,3-dihydroindol-2-ones is ...

Synthesis, characterization, and biological evaluations of some steryl 2-methoxybenzoates as anticancer agents

Yanmin Huang (1515796)
Haiyan Wen (5042123)
Jiahua Zheng (5042117)
Chunfang Gan (5042120)
Liping Pang (5042126)
Chunling Pang (5042129)
Xiaolan Liu (294511)
Junyan Zhan (2091145)
Jianguo Cui (292488)

March 2018

<p>Using cholesterol, stigmasterol and sitosterol as starting materials, a series of 7-subsitituted-...

Synthesis and Cytotoxic Effects of 3,6-Bis-indolyl 2,5-Dihydroxybenzoquinone Acetates

Tsanakopoulou, M. Dalezis, P. Karakousi, C.-V. Schina, D. Trafalis, D. Malamidou-Xenikaki, E. Sarli, V.

January 2022

The synthesis of a novel series of indolyl-2,5-dihydroxybenzoquinone derivatives, analogues of aster...

Synthesis and characterization of new diketone analogues of podophyllotoxin

Hemakumar, K. H.
Sathisha, A. D.
Basavaraju, Y. B.

January 2008

The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-...

Antitumor Agents. 5. Synthesis, Structure-Activity Relationships, and Biological Evaluation of Dimethyl-5H-pyridophenoxazin-5-ones, Tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-Benzopyridophenoxazin-5-ones with Potent Antiproliferative Activity

ADELE BOLOGNESE
GAETANO CORREALE
ANTONIO LAVECCHIA
ETTORE NOVELLINO
AND STEFANO PEPE
MANFRA, MICHELE

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5Hbenz...

Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity

BOLOGNESE A.
CORREALE G.
MANFRA M.
LAVECCHIA, ANTONIO
NOVELLINO, ETTORE
PEPE S.

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5H-ben...

D-ring modified paclitaxel analogues and approaches towards 1,7-dideoxypaclitaxel analogues from taxine

Beusker, P.H.

January 2002

Paclitaxel (Taxol©) is one of the most effective anticancer agents known to man to date. It acts by ...

Antitumor Agents. 5. Synthesis, structure−activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity.

A.Bolognese
G.Correale
M.Manfra
A.La Vecchia
E.Novellino
S.Pepe.

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1−6), tetrahydro-5H-ben...

Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390

BARBONI, Luciano
BALLINI, Roberto
GIARLO, Guido
APPENDINO G.
FONTANA G.
BOMBARDELLI E.

January 2005

Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer g...

14Beta-Hydroxy-10-deacetylbaccatin III as a Convenient, Alternative Substrate for the Improved Synthesis of Methoxylated Second-Generation Taxanes

BARBONI, Luciano
GIARLO, Guido
BALLINI, Roberto
FONTANA G.

January 2006

This article describes a new, convenient, improved synthesis of the 2-debenzoyl-2-m-methoxybenzoyl-7...

Design, Synthesis and Biological Evaluation of New Generation

January 2016

Novel second-generation taxoids with systematic modifications at the C2, C10, and C3’N positions wer...

‘Synthesis and Biological Evaluation of New Taxoids Derived from 2-Deacetoxytaxinine J’

BOTTA, MAURIZIO
S. ARMAROLI
D. CASTAGNOLO
G. FONTANA
P. PERA
E. BOMBARDELLI

January 2007

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro f...

SYNTHESIS AND MOLECULAR MODELING OF TAXANES MODIFIED AT RING-C

MENICHINCHERI M
CECCARELLI W
CIOMEI M
DANELLO M
FUSARBASSINI D
MONGELLI N
PESENTI E
PINCIROLI V
VANOTTI E.
BOTTA, MAURIZIO
CORELLI, FEDERICO
TAFI, ANDREA

January 1995

Some new paclitaxel analogs, modified at ring C, - namely the 7-alpha-mesylate, 7-deoxy-7-alpha-amin...

Synthesis and biological evaluation of novel taxane terpenoids

Gasiorowski, Stephanie
Tischler, Jessica L.
Zand, Ali R.

March 2004

Paclitaxel, a diterpene natural product from the Pacific Yew tree, Taxus brevifolia, has emerged as ...

Overcoming tumor drug resistance with high-affinity taxanes: A SAR study of C2-modified 7-acyl-10-deacetyl cephalomannines

Yang, Chun-Gang
Barasoain, Isabel
Li, Xuan
Matesanz, Ruth
Liu, Ronghua
Sharom, Frances J.
Yin, Da-Li
Díaz, José Fernando
Fang, Wei-Shuo

October 2021

A series of C2-modified 10-deacetyl-7-propionyl cephalomannine derivatives was designed, prepared, a...

Antitumor Activity of Substituted E-3-(3,4,5-Trimethoxybenzylidene)-1,3-dihydroindol-2-ones

ANDREANI, ALDO
BURNELLI, SILVIA
GRANAIOLA, MASSIMILIANO
LEONI, ALBERTO
LOCATELLI, ALESSANDRA
MORIGI, RITA
RAMBALDI, MIRELLA
VAROLI, LUCILLA
M. W. Kunkel

January 2006

The design and synthesis of anticancer E-3-(3,4,5-trimethoxybenzilidene)-1,3-dihydroindol-2-ones is ...

Synthesis, characterization, and biological evaluations of some steryl 2-methoxybenzoates as anticancer agents

Yanmin Huang (1515796)
Haiyan Wen (5042123)
Jiahua Zheng (5042117)
Chunfang Gan (5042120)
Liping Pang (5042126)
Chunling Pang (5042129)
Xiaolan Liu (294511)
Junyan Zhan (2091145)
Jianguo Cui (292488)

March 2018

<p>Using cholesterol, stigmasterol and sitosterol as starting materials, a series of 7-subsitituted-...

Synthesis and Cytotoxic Effects of 3,6-Bis-indolyl 2,5-Dihydroxybenzoquinone Acetates

Tsanakopoulou, M. Dalezis, P. Karakousi, C.-V. Schina, D. Trafalis, D. Malamidou-Xenikaki, E. Sarli, V.

January 2022

The synthesis of a novel series of indolyl-2,5-dihydroxybenzoquinone derivatives, analogues of aster...

Synthesis and characterization of new diketone analogues of podophyllotoxin

Hemakumar, K. H.
Sathisha, A. D.
Basavaraju, Y. B.

January 2008

The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-...

Antitumor Agents. 5. Synthesis, Structure-Activity Relationships, and Biological Evaluation of Dimethyl-5H-pyridophenoxazin-5-ones, Tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-Benzopyridophenoxazin-5-ones with Potent Antiproliferative Activity

ADELE BOLOGNESE
GAETANO CORREALE
ANTONIO LAVECCHIA
ETTORE NOVELLINO
AND STEFANO PEPE
MANFRA, MICHELE

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5Hbenz...

Antitumor agents. 5. synthesis, structure-activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5h-benzopyridophenoxazin-5-ones, and 5h-benzopyridophenoxazin-5-ones with potent antiproliferative activity

BOLOGNESE A.
CORREALE G.
MANFRA M.
LAVECCHIA, ANTONIO
NOVELLINO, ETTORE
PEPE S.

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1-6), tetrahydro-5H-ben...

D-ring modified paclitaxel analogues and approaches towards 1,7-dideoxypaclitaxel analogues from taxine

Beusker, P.H.

January 2002

Antitumor Agents. 5. Synthesis, structure−activity relationships, and biological evaluation of dimethyl-5H-pyridophenoxazin-5-ones, tetrahydro-5H-benzopyridophenoxazin-5-ones, and 5H-benzopyridophenoxazin-5-ones with potent antiproliferative activity.

A.Bolognese
G.Correale
M.Manfra
A.La Vecchia
E.Novellino
S.Pepe.

January 2006

New antiproliferative compounds, dimethyl-5H-pyrido[3,2-a]phenoxazin-5-ones (1−6), tetrahydro-5H-ben...

Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390

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