Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process

S. CAMPETELLA
PALMIERI, Alessandro
PETRINI, Marino

Publication date

January 2009

DOI

10.1002/ejoc.200900222

Publisher

Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328

ISSN

1434-193X

Citation count (estimate)

Abstract

Reaction of indazoles with aldehydes in the presence of p-toluenesulfinic acid affords the corresponding sulfonyl indazoles in satisfactory yields. The reported Friedel-Crafts process is rather unusual on indazoles because of the reduced electronic density of the heterocycle. The obtained sulfonyl indazoles can be desulfonylated under reductive conditions, finally leading to 3-alkylated indazoles

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Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process

Abstract

Extracted data

Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process

Abstract

Extracted data

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