Mesoporous silica nanoparticles (MSNs), based on the MCM-41 matrix, were functionalized with amino groups, and then with hyaluronic acid (HA) or chitosan (CHIT) to fabricate bioactive conjugates. The role of the functional groups toward cytotoxicity and cellular uptake was investigated using 3T3 mouse fibroblast cells. A very high biocompatibility of MSN-NH2, MSN-HA and MSN-CHIT matrices was assessed through the MTS biological assay and Coulter counter evaluation. No significant differences in cytotoxicity data arise from the presence of different functional groups in the investigated MSNs. Fluorescence microscopy experiments performed using fluorescein isothiocyanate-conjugated MSN-NH2, MSN-HA, and MSN-CHIT, and transmission electron micro...
International audienceSilica nanoparticles are particularly interesting for medical applications bec...
The research discussed in this thesis is divided into a total of five chapters, and divided into two...
National audienceSilica nanoparticles are particularly interesting for medical applications because ...
Mesoporous silica nanoparticles (MSNs), based on the MCM-41 matrix, were functionalized with amino g...
Mesoporous silica nanoparticles (MSNs), based on the MCM-41 matrix, were functionalized with amino g...
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2) and then with...
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2) and then with...
Biomedical application of nanoparticles is largely associated to their fate in biological media whic...
We have synthesized a series of MCM-41-type mesoporous silica nanoparticles (MSN). The surface of th...
We report different mesoporosity-dependent and functional group-dependent cytotoxicity and endocytos...
Biomacromolecules, such as miRNA/siRNA and proteins, have been drawing increasing attention because ...
Biomedical application of nanoparticles is largely associated to their fate in biological media whic...
International audienceNanoparticles (NP) physico-chemical features greatly influence NP/cell interac...
Mesoporous materials synthesized in the presence of templates, are commonly used for environment and...
We have prepared and evaluated the physico-chemical and biological properties of four different hyal...
International audienceSilica nanoparticles are particularly interesting for medical applications bec...
The research discussed in this thesis is divided into a total of five chapters, and divided into two...
National audienceSilica nanoparticles are particularly interesting for medical applications because ...
Mesoporous silica nanoparticles (MSNs), based on the MCM-41 matrix, were functionalized with amino g...
Mesoporous silica nanoparticles (MSNs), based on the MCM-41 matrix, were functionalized with amino g...
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2) and then with...
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2) and then with...
Biomedical application of nanoparticles is largely associated to their fate in biological media whic...
We have synthesized a series of MCM-41-type mesoporous silica nanoparticles (MSN). The surface of th...
We report different mesoporosity-dependent and functional group-dependent cytotoxicity and endocytos...
Biomacromolecules, such as miRNA/siRNA and proteins, have been drawing increasing attention because ...
Biomedical application of nanoparticles is largely associated to their fate in biological media whic...
International audienceNanoparticles (NP) physico-chemical features greatly influence NP/cell interac...
Mesoporous materials synthesized in the presence of templates, are commonly used for environment and...
We have prepared and evaluated the physico-chemical and biological properties of four different hyal...
International audienceSilica nanoparticles are particularly interesting for medical applications bec...
The research discussed in this thesis is divided into a total of five chapters, and divided into two...
National audienceSilica nanoparticles are particularly interesting for medical applications because ...