Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells
- Sapienza, Silvia
- Tedeschi, Valentina
- Apicella, Barbara
- Palestra, Francesco
- Russo, Carmela
- Piccialli, Ilaria
- Pannaccione, Anna
- Loffredo, Stefania
- Secondo, Agnese
DOIAbstract
An emerging body of evidence indicates an association between anthropogenic particulate matter (PM) and neurodegeneration. Although the historical focus of PM toxicity has been on the cardiopulmonary system, ultrafine PM particles can also exert detrimental effects in the brain. However, only a few studies are available on the harmful interaction between PM and CNS and on the putative pathomechanisms
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