Add to ORKGBackground: the concentration of purine and pyrimidine metabolites in urine is useful marker of defects in their biosynthetic pathways or in the urea-cycle. Matherials and Methods: urine were collected from 58 healthy subjects aged from <2years to 42 years. The separation was performed with HPLC method. The same urine sample were examined using 1H-NMR. Results: HPLC and 1H-NMR method allowed the identification of 13 purine and pyrimidine compounds (orotic acid, creatinine, uracil, uric acid, hypoxantine, xanthine, uridine, thymine, inosine, guanosine, deoxyinosine, deoxyguanosine, deoxyadenosine). For each compound we have established reference ranges of concentration. The results point out that some compounds show a different urinary ex...
Excretion patterns of pyrimidines and purines in patients with various types of hyperammonemia have ...
Background: Clinical presentation and disease severity in disorders of purine and pyrimidine metabol...
SUMMARY-High-resolution liquid chromatographic pro-cedures for the separation and analysis of severa...
Background: the concentration of purine and pyrimidine metabolites in urine is useful marker of defe...
The large amount of uric acid in the urine of human subjects has overshadowed several other purines ...
Summary: We investigated the urinary excretion of ribonucleosides and an unidentified substance in 3...
Background and aimsInborn errors of purine and pyrimidine metabolism are a diverse group of disorder...
Objectives: To develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantif...
Background: The concentrations of the pyrimidine de novo metabolites and their degradation products ...
Background and aimsInborn errors of purine and pyrimidine metabolism are a diverse group of disorder...
BACKGROUND Clinical presentation and disease severity in disorders of purine and pyrimidine metaboli...
Purine metabolism is essential for all known living creatures, including humans in whom elevated ser...
Modified nucleosides have been characterized as tumor markers for a number of malignant diseases. In...
We describe the group selective separation and quantification of unmodified and modified purines in ...
BACKGROUND AND AIMS:Inborn errors of purine and pyrimidine metabolism are a diverse group of disorde...
Excretion patterns of pyrimidines and purines in patients with various types of hyperammonemia have ...
Background: Clinical presentation and disease severity in disorders of purine and pyrimidine metabol...
SUMMARY-High-resolution liquid chromatographic pro-cedures for the separation and analysis of severa...
Background: the concentration of purine and pyrimidine metabolites in urine is useful marker of defe...
The large amount of uric acid in the urine of human subjects has overshadowed several other purines ...
Summary: We investigated the urinary excretion of ribonucleosides and an unidentified substance in 3...
Background and aimsInborn errors of purine and pyrimidine metabolism are a diverse group of disorder...
Objectives: To develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantif...
Background: The concentrations of the pyrimidine de novo metabolites and their degradation products ...
Background and aimsInborn errors of purine and pyrimidine metabolism are a diverse group of disorder...
BACKGROUND Clinical presentation and disease severity in disorders of purine and pyrimidine metaboli...
Purine metabolism is essential for all known living creatures, including humans in whom elevated ser...
Modified nucleosides have been characterized as tumor markers for a number of malignant diseases. In...
We describe the group selective separation and quantification of unmodified and modified purines in ...
BACKGROUND AND AIMS:Inborn errors of purine and pyrimidine metabolism are a diverse group of disorde...
Excretion patterns of pyrimidines and purines in patients with various types of hyperammonemia have ...
Background: Clinical presentation and disease severity in disorders of purine and pyrimidine metabol...
SUMMARY-High-resolution liquid chromatographic pro-cedures for the separation and analysis of severa...