Add to ORKG6-Hydroxydopa and 6-hydroxydopamine undergo autoxidation in the presence of molecular oxygen giving rise to the corresponding p-quinones. NAD(P)H:quinone oxidoreductase (QR) purified from Glycine max showed that it inhibited autoxidation of 6-hydroxydopa and 6-hydroxydopamine. The inhibition of autoxidation of 6-hydroxydopa was greater than B-hydroxydopamine. QR had a potentiated effect in preventing 6-hydroxydopa oxidation in the presence of catalase and superoxide dismutase. Reduced glutathione increased protective effect when incubated with QR on both 6-hydroxydopa and B-hydroxydopamine. Homogenized tissues from rat brain also showed to inhibit 6-hydroxydopa autoxidation. Our observations suggest a possible role for brain NAD(P)H:quinone...
There is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of n...
The amino acid, 6-hydroxydopa (6-OHDOPA), found at the active site of amine oxidases, exists as a ke...
AbstractMenadione elicits low-level chemiluminescence (λ >620 nm) associated with redox cycling of t...
The autooxidation of L-Dopa, a catecholamine used in the symptomatic treatment of Parkinson's diseas...
The spontaneous autoxidation of the neurotoxin 6-hydroxydopamine proceeds by a free radical chain re...
An NAD(P)H:(quinone acceptor) oxidoreductase (EC 1.6.99.2) was purified from Glycine max seedlings b...
6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegene...
Experiments using purified recombinant human NAD(P)H:qui-none oxidoreductase 1 (NQO1) revealed that ...
peer reviewedDue to their chemical nature, dopamine and its metabolites are easily oxidized—a proces...
6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transpo...
In vitro experiments are reported showing that NAD(P)H:(quinone acceptor) oxidoreductase (QR), purif...
AbstractThe study has demonstrated that dopamine induces membrane depolarization and a loss of phosp...
Melatonin, a naturally occuring chemical mediator, although assigned a diverse range of functions, h...
Autoxidation of the bis(0-demethy1)-p-hydroquinone metabolite of the psychotomimetic amine l-(2,5-di...
AbstractSeveral studies on mitochondrial functions following brief exposure (5–15 min) to dopamine (...
There is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of n...
The amino acid, 6-hydroxydopa (6-OHDOPA), found at the active site of amine oxidases, exists as a ke...
AbstractMenadione elicits low-level chemiluminescence (λ >620 nm) associated with redox cycling of t...
The autooxidation of L-Dopa, a catecholamine used in the symptomatic treatment of Parkinson's diseas...
The spontaneous autoxidation of the neurotoxin 6-hydroxydopamine proceeds by a free radical chain re...
An NAD(P)H:(quinone acceptor) oxidoreductase (EC 1.6.99.2) was purified from Glycine max seedlings b...
6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegene...
Experiments using purified recombinant human NAD(P)H:qui-none oxidoreductase 1 (NQO1) revealed that ...
peer reviewedDue to their chemical nature, dopamine and its metabolites are easily oxidized—a proces...
6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transpo...
In vitro experiments are reported showing that NAD(P)H:(quinone acceptor) oxidoreductase (QR), purif...
AbstractThe study has demonstrated that dopamine induces membrane depolarization and a loss of phosp...
Melatonin, a naturally occuring chemical mediator, although assigned a diverse range of functions, h...
Autoxidation of the bis(0-demethy1)-p-hydroquinone metabolite of the psychotomimetic amine l-(2,5-di...
AbstractSeveral studies on mitochondrial functions following brief exposure (5–15 min) to dopamine (...
There is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of n...
The amino acid, 6-hydroxydopa (6-OHDOPA), found at the active site of amine oxidases, exists as a ke...
AbstractMenadione elicits low-level chemiluminescence (λ >620 nm) associated with redox cycling of t...