The effect of propofol, a novel short acting anaesthetic, on the function of the GABA(A)/ionophore receptor complex was studied in vitro in cortical membrane preparations from rat cerebral cortex and was compared with the action of pentobarbital and alphaxalone, two general anaesthetics known to enhance GABAergic transmission. Propofol, mimicking the action of pentobarbital and alphaxalone, increased [H-3]GABA binding, reduced [S-35]TBPS binding and enhanced muscimol-stimulated Cl-36- uptake in a concentration-dependent manner. While the efficacy of the drugs in affecting these biochemical parameters was similar, they differed markedly in potency being alphaxalone > propofol > pentobarbital. However, separate sites of action or different me...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
The effect of propofol, a novel short acting anaesthetic, on the function of the GABA(A)/ionophore r...
The effect of the general anesthetic propofol on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) bi...
The effect of the general anesthetic propofol on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) bi...
The effect of the general anesthetic propofol on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) bi...
The influence of propofol, a new intravenous anesthetic agent, on brain gamma-aminobutyric acid (GAB...
The effects of loreclezole on the function of the gamma-aminobutyric acid type A. (GABA(A)) receptor...
The effects of loreclezole on the function of the gamma-aminobutyric acid type A. (GABA(A)) receptor...
1. Pharmacological evidence suggests that some of the clinical actions of propofol may be mediated, ...
The effects of propofol, pentobarbital, alphaxalone, etomidate and diazepam on t-[35S]butylbicycloph...
The effects of propofol, pentobarbital, alphaxalone, etomidate and diazepam on t-[35S]butylbicycloph...
1. Pharmacological evidence suggests that some of the clinical actions of propofol may be mediated, ...
GABAA receptors are predominantly composed of and isoforms in the brain. It has been proposed tha...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
The effect of propofol, a novel short acting anaesthetic, on the function of the GABA(A)/ionophore r...
The effect of the general anesthetic propofol on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) bi...
The effect of the general anesthetic propofol on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) bi...
The effect of the general anesthetic propofol on t-[35S]butylbicyclophosphorothionate ([35S]TBPS) bi...
The influence of propofol, a new intravenous anesthetic agent, on brain gamma-aminobutyric acid (GAB...
The effects of loreclezole on the function of the gamma-aminobutyric acid type A. (GABA(A)) receptor...
The effects of loreclezole on the function of the gamma-aminobutyric acid type A. (GABA(A)) receptor...
1. Pharmacological evidence suggests that some of the clinical actions of propofol may be mediated, ...
The effects of propofol, pentobarbital, alphaxalone, etomidate and diazepam on t-[35S]butylbicycloph...
The effects of propofol, pentobarbital, alphaxalone, etomidate and diazepam on t-[35S]butylbicycloph...
1. Pharmacological evidence suggests that some of the clinical actions of propofol may be mediated, ...
GABAA receptors are predominantly composed of and isoforms in the brain. It has been proposed tha...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...
1. The interaction of the intravenous general anaesthetic propofol (2,6-diisopropylphenol) with the ...