Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones

AITKEN DJ
BERNARD AM
CAPITTA F
FRONGIA A
GUILLOT R
OLLIVIER J
PIRAS PP
SECCI F
SPIGA M

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Publication date

January 2012

DOI

10.1039/c2ob25813g

Publisher

Royal Society of Chemistry (RSC)

ISSN

1477-0520

Citation count (estimate)

Abstract

N-Phenylsulfonyl (S)-proline catalyzes the direct aldol reaction of 3-substituted cyclobutanones and aryl aldehydes in good yield and with excellent diastereoselectivity and enantioselectivity. This desymmetrization process provides highly functionalized cyclobutanones with control over three contiguous stereogenic centers

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Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones

Abstract

Extracted data

Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones

Abstract

Extracted data

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