The chemokine CCL5 affects the binding of the envelop protein gp120 to the co-receptor CCR5. CCL5 also prevents neuronal cell death mediated by the X4 gp120 and Tat, which have no affinity for CCR5. The mechanism of action of this chemokine remains to be fully characterized. Recent studies and preliminary data have shown that CCL5 activates a GPR75 which belongs to the Gqα family. This receptor is more abundant in the brain than in the immune organs. Moreover, CCL5 activates various pro-survival signaling molecules, including inositol triphosphate, phosphatidylinositol 3-kinase and its downstream targets, protein kinase B (Akt) and extracellular signal-regulated kinases (ERK1/2), in SH-SY5Y human neuroblastoma cells. These cells do no...
CCR5 is expressed in neurons but its function in this cellular context is hitherto poorly understood...
The C-C chemokine receptor type 5, CCR5, is expressed on various cell types and is involved in a la...
International audienceThe chemokine receptor CCR5 has been the focus of intensive studies since its ...
The chemokine CCL5 affects the binding of the envelop protein gp120 to the co-receptor CCR5. CCL5 al...
The chemokine CCL5 inhibits entry of M-tropic HIV strains into macrophages/microglia by affecting th...
The chemokine CCL5 prevents neuronal cell death mediated both by amyloid β, as well as the human imm...
Words 4,988 Chemokine receptors typically elicit chemotaxis of leukocytes, mediating homeostatic an...
C-C chemokine receptor 5 (CCR5) is a chemokine receptor belonging to the G protein-coupled receptor ...
Because of the level of attention it received due to its role as the principal HIV coreceptor, CCR5 ...
Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12...
CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that governs migration of leukocytes ...
The innate immune system has been implicated in several neurodegenerative diseases, including HIV-1-...
CCR5 was first characterized as a receptor for MIP-1alpha, MIP-1beta, and RANTES, and was rapidly sh...
The CC chemokine receptor 5 (CCR5) is a member of CCchemokine receptor family. CCR5 has the characte...
CC chemokine receptor 5 (CCR5), the major HIV coreceptor, is a G protein-coupled receptor (GPCR) inv...
CCR5 is expressed in neurons but its function in this cellular context is hitherto poorly understood...
The C-C chemokine receptor type 5, CCR5, is expressed on various cell types and is involved in a la...
International audienceThe chemokine receptor CCR5 has been the focus of intensive studies since its ...
The chemokine CCL5 affects the binding of the envelop protein gp120 to the co-receptor CCR5. CCL5 al...
The chemokine CCL5 inhibits entry of M-tropic HIV strains into macrophages/microglia by affecting th...
The chemokine CCL5 prevents neuronal cell death mediated both by amyloid β, as well as the human imm...
Words 4,988 Chemokine receptors typically elicit chemotaxis of leukocytes, mediating homeostatic an...
C-C chemokine receptor 5 (CCR5) is a chemokine receptor belonging to the G protein-coupled receptor ...
Because of the level of attention it received due to its role as the principal HIV coreceptor, CCR5 ...
Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12...
CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that governs migration of leukocytes ...
The innate immune system has been implicated in several neurodegenerative diseases, including HIV-1-...
CCR5 was first characterized as a receptor for MIP-1alpha, MIP-1beta, and RANTES, and was rapidly sh...
The CC chemokine receptor 5 (CCR5) is a member of CCchemokine receptor family. CCR5 has the characte...
CC chemokine receptor 5 (CCR5), the major HIV coreceptor, is a G protein-coupled receptor (GPCR) inv...
CCR5 is expressed in neurons but its function in this cellular context is hitherto poorly understood...
The C-C chemokine receptor type 5, CCR5, is expressed on various cell types and is involved in a la...
International audienceThe chemokine receptor CCR5 has been the focus of intensive studies since its ...