To study amalgam-related toxicity in a primary target cell type, human oral fibroblasts were grown in a low-serum medium containing 1.25% fetal bovine serum and exposed to Hg2+, a corrosion product of amalgam. A 1-h exposure to various concentrations of Hg2+ resulted in a dose-dependent loss of colony forming efficiency. Removal of the low-molecular-weight thiol cysteine from the medium increased the toxicity of Hg2+ almost 50-fold in comparison with complete medium or medium without fetal bovine serum. Accordingly, fetal bovine serum was not found to contain detectable levels of low-molecular-weight thiols. The levels of cellular free protein thiols were shown to be depleted by Hg2+ at significantly lower concentrations of the metal ion th...
The in vitro cytotoxicity of nine metal cations common in dental casting alloys was evaluated usin...
Abstract Formation of stable complexes with protein thiols is the best-known mechanism of mercury to...
The effects of 1 min – 4 hr exposures to mercuric chloride (HgCl2), methyl mercuric chloride (CH3HgC...
With the aim of establishing conditions applicable to the testing of dental materials in human targe...
In the present study, we have investigated the effects of extracellular redox status and metal/thiol...
Mercury toxicity mediated by different forms of mercury is a major health problem; however, the mole...
The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). T...
Simultaneous or prior exposure to one chemical may alter the concurrent or subsequent response to an...
AbstractThis study shows that the intracellular concentration of homocysteine in cultured cells is k...
Hydrogen sulphide and methyl mercaptan are intermediate volatile metabolites produced in the oral ca...
In vivo Hg(II) exists as a complex with endogenous ligands, not as a free ion. Previous in vitro stu...
There are very few studies on the interaction between dental alloys and oral tissues. The effect of ...
Thiol modifications during growth and differentiation of cultured normal human bronchial epithelial ...
Heavy metal toxicity represents an uncommon but clinically significant medical condition, which if u...
The chemical and biological factors controlling microbial formation of methylmercury (MeHg) are wide...
The in vitro cytotoxicity of nine metal cations common in dental casting alloys was evaluated usin...
Abstract Formation of stable complexes with protein thiols is the best-known mechanism of mercury to...
The effects of 1 min – 4 hr exposures to mercuric chloride (HgCl2), methyl mercuric chloride (CH3HgC...
With the aim of establishing conditions applicable to the testing of dental materials in human targe...
In the present study, we have investigated the effects of extracellular redox status and metal/thiol...
Mercury toxicity mediated by different forms of mercury is a major health problem; however, the mole...
The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). T...
Simultaneous or prior exposure to one chemical may alter the concurrent or subsequent response to an...
AbstractThis study shows that the intracellular concentration of homocysteine in cultured cells is k...
Hydrogen sulphide and methyl mercaptan are intermediate volatile metabolites produced in the oral ca...
In vivo Hg(II) exists as a complex with endogenous ligands, not as a free ion. Previous in vitro stu...
There are very few studies on the interaction between dental alloys and oral tissues. The effect of ...
Thiol modifications during growth and differentiation of cultured normal human bronchial epithelial ...
Heavy metal toxicity represents an uncommon but clinically significant medical condition, which if u...
The chemical and biological factors controlling microbial formation of methylmercury (MeHg) are wide...
The in vitro cytotoxicity of nine metal cations common in dental casting alloys was evaluated usin...
Abstract Formation of stable complexes with protein thiols is the best-known mechanism of mercury to...
The effects of 1 min – 4 hr exposures to mercuric chloride (HgCl2), methyl mercuric chloride (CH3HgC...