Eight new dermorphin peptides, X-C6H4-CH2CH2CO-D-Ala-Phe-(L or D)-Yaa-NH2 [X = H, OH; Y = lysine, homoarginine (Har)], were prepared and tested by binding assays. They show negligible affinity for mu-, delta- and K-receptor sites. These findings indicate that the N-terminal ammonium group can not be replaced by the ammonium or guanidinium function located at the side-chain in Lys or Har derivatives
The Phe 3 residue of the N-terminal tetrapeptide of dermorphin (H-Dmt-d-Ala-Phe-Gly-NH 2) was confor...
We describe the synthesis and preliminary in vitro pharmacological testing of two new tetrapeptide a...
Syntheses are described of new dermorphin and [D-Ala(2)]deltorphin I analogues in which the phenylal...
Eight new dermorphin peptides, X-C6H4-CH2CH2CO-D-Ala-Phe-(L or D)-Yaa-NH2 [X = H, OH; Y = lysine, ho...
C-Terminal amino acid residues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) were replaced by ...
C-Terminal amino acid residues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) were replaced by ...
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2--NH2 (1a), H-Tyr-D-Ala-Phe-psi (CH2--...
Sixteen dermorphin analogues were synthesized and characterized for mu- and delta-opioid receptor bi...
The Gly 4 and/or Tyr 5 residues in dermorphin hexapeptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-OH) were repl...
A new series of 12 dermorphin tetrapeptides, W-Tyr-D-MetO-Phe-Xaa-Y (W = H, H2NC = (NH); Xaa = Gly, ...
The N-terminal dipeptide Tyr-d-Ala of a mu-selective agonist, dermorphin tetrapeptide (DT, H-Tyr-D-A...
Dermorphin structure-activity relationships toward \u3bc and \u3b4 opioid receptors were investigate...
AbstractFour new [d-MetO2]dermorphin tetrapeptides with substituted N- and C-terminal groups and a t...
We studied the effect of partial retro-inverso modification of a selected peptide bond of dermorphin...
Syntheses are described of new dermorphin and [D-Ala(2)]deltorphin I analogues in which the phenylal...
The Phe 3 residue of the N-terminal tetrapeptide of dermorphin (H-Dmt-d-Ala-Phe-Gly-NH 2) was confor...
We describe the synthesis and preliminary in vitro pharmacological testing of two new tetrapeptide a...
Syntheses are described of new dermorphin and [D-Ala(2)]deltorphin I analogues in which the phenylal...
Eight new dermorphin peptides, X-C6H4-CH2CH2CO-D-Ala-Phe-(L or D)-Yaa-NH2 [X = H, OH; Y = lysine, ho...
C-Terminal amino acid residues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) were replaced by ...
C-Terminal amino acid residues of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) were replaced by ...
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2--NH2 (1a), H-Tyr-D-Ala-Phe-psi (CH2--...
Sixteen dermorphin analogues were synthesized and characterized for mu- and delta-opioid receptor bi...
The Gly 4 and/or Tyr 5 residues in dermorphin hexapeptide (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-OH) were repl...
A new series of 12 dermorphin tetrapeptides, W-Tyr-D-MetO-Phe-Xaa-Y (W = H, H2NC = (NH); Xaa = Gly, ...
The N-terminal dipeptide Tyr-d-Ala of a mu-selective agonist, dermorphin tetrapeptide (DT, H-Tyr-D-A...
Dermorphin structure-activity relationships toward \u3bc and \u3b4 opioid receptors were investigate...
AbstractFour new [d-MetO2]dermorphin tetrapeptides with substituted N- and C-terminal groups and a t...
We studied the effect of partial retro-inverso modification of a selected peptide bond of dermorphin...
Syntheses are described of new dermorphin and [D-Ala(2)]deltorphin I analogues in which the phenylal...
The Phe 3 residue of the N-terminal tetrapeptide of dermorphin (H-Dmt-d-Ala-Phe-Gly-NH 2) was confor...
We describe the synthesis and preliminary in vitro pharmacological testing of two new tetrapeptide a...
Syntheses are described of new dermorphin and [D-Ala(2)]deltorphin I analogues in which the phenylal...