The mRNA and protein expression of the alpha- and beta-chains of IFN-gammaR were evaluated on a panel of human Th1 and Th2 clones. When cultured in IL-2-conditioned medium, both types of clones expressed mRNA for the alpha- and beta-chains, and both chains were present in the cytoplasm. Membrane expression of the alpha-chain was higher on Th2 than on Th1, whereas the beta-chain was poorly expressed on both types but increased following IL-2 withdrawal or PHA stimulation. In addition, both types of clones overexpressed MHC class I glycoproteins following IFN-gammaR triggering by exogenous IFN-gamma, although the kinetics was slower in Th1, and this exposure induced mRNA for IRF-1. When their TCR was triggered in the absence of APC, Th1 only ...
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptiona...
: IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory...
The effect of interferons (IFNs) type I (alpha/beta) and type II (gamma) on the stimulation of H2-D(...
The mRNA and protein expression of the alpha- and beta-chains of IFN-gammaR were evaluated on a pane...
The surface and cytoplasmic expressions of the transducing chain (IFN-gamma R2) of the heterodimeric...
Type I IFNs (IFN-alphabeta) enhance immune responses, notably T cell-mediated responses, in part by ...
The biological role of the murine IFN-gamma endogenously secreted during cell activation has been pr...
A full-length cDNA encoding the murine interferon gamma (IFN-gamma) receptor was isolated from a lam...
The type I interferons (IFN) are a family of cytokines with pleiothropic activities that include inh...
Interferons (IFNs) are potent, pleiotropic cytokines, and therefore it is likely that the cell has m...
: IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial c...
The present study examined cellular mechanisms involved in the production and secretion of human (ga...
The cytokine interferon-gamma (IFN-gamma), initiates both cell cycle arrest and cell death in certai...
The basic framework for the JAK/STAT pathway is well documented. Recruitment of latent cytoplasmic S...
Our previous study demonstrated that IL-2 suppressed growth of human T cell lines, in which the supp...
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptiona...
: IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory...
The effect of interferons (IFNs) type I (alpha/beta) and type II (gamma) on the stimulation of H2-D(...
The mRNA and protein expression of the alpha- and beta-chains of IFN-gammaR were evaluated on a pane...
The surface and cytoplasmic expressions of the transducing chain (IFN-gamma R2) of the heterodimeric...
Type I IFNs (IFN-alphabeta) enhance immune responses, notably T cell-mediated responses, in part by ...
The biological role of the murine IFN-gamma endogenously secreted during cell activation has been pr...
A full-length cDNA encoding the murine interferon gamma (IFN-gamma) receptor was isolated from a lam...
The type I interferons (IFN) are a family of cytokines with pleiothropic activities that include inh...
Interferons (IFNs) are potent, pleiotropic cytokines, and therefore it is likely that the cell has m...
: IL-1 induces its own gene expression in human PBMC, in cultured smooth muscle and in endothelial c...
The present study examined cellular mechanisms involved in the production and secretion of human (ga...
The cytokine interferon-gamma (IFN-gamma), initiates both cell cycle arrest and cell death in certai...
The basic framework for the JAK/STAT pathway is well documented. Recruitment of latent cytoplasmic S...
Our previous study demonstrated that IL-2 suppressed growth of human T cell lines, in which the supp...
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptiona...
: IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory...
The effect of interferons (IFNs) type I (alpha/beta) and type II (gamma) on the stimulation of H2-D(...