Quantitative structure activity relationship studies on a series of 1,3-diaryl-4,5,6, 7-tetrahydro-2H-isoindole derivatives as potent and selective Cox-2 inhibitors

Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India E-mail : qsarlab_am@rediffmail.com Manuscript received 7 November 2006, accepted 10 January 2007 The quantitative structure activity relationship (QSAR) of analogues of diary! tetrahydroisoindole focusing on the modification of the ring fused to pyrrole nucleus, is discussed. The anti-inflammatory activity of these compounds is found to be dominantly controlled by electronic and steric factors, Xeq and 1אv in combination with indicator parameters