This paper is a natural prosecution of two previous works. We present a web geospatial framework for analyzing and monitoring the spatio-temporal evolution of disease hotspots. In order to detect the hotspots, we adopt Extended Fuzzy C-Means method which has been adapted for calculating spatial areas with high concentrations of events in a Geographic Information System and tested to study the spatial and temporal evolution of hotspot areas. Each event is given by the geo-positional coordinates of the place of residence of the patient. The analyst can insert event data directly on the map or digitizing the address of the residence of the patient and by using geo-coding services for locating the event. The events can be grouped for time inter...