Identification of prognostic factors predicting outcome in Hodgkin's lymphoma patients relapsing after autologous stem cell transplantation

C Martínez
C Canals
B Sarina
EP Alessandrino
D Karakasis
A Pulsoni
S Sica
M Trneny
JA Snowden
E Kanfer
N Milpied
A Bosi
S Guidi
CA de Souza
R Willemze
R Arranz
L Jebavy
A Hellmann
D Sibon
R Oneto
JJ Luan
P Dreger
L Castagna
A Sureda

Open link

Publication date

January 2013

DOI

10.1093/annonc/mdt206

Publisher

Oxford University Press (OUP)

Abstract

Background: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard of care for patients with relapsed Hodgkin's lymphoma (HL). However, there is currently little information on the predictors of outcome for patients whose disease recurs after ASCT. Methods: Five hundred and eleven adult patients with relapsed HL after ASCT from EBMT-GITMO databases were reviewed. Results: Treatments administered following ASCT failure included conventional chemotherapy and/or radiotherapy in 294 (64%) patients, second ASCT in 35 (8%), and alloSCT in 133 (29%). After a median follow-up of 49 months, overall survival (OS) was 32% at 5 years. Independent risk factors for OS were early relapse (<6 months) after ASCT, stag...