Thrombosis and survival in essential thrombocythemia: A regional study of 1,144 patients
- Marco Montanaro
- Roberto Latagliata
- Michele Cedrone
- Antonio Spadea
- Angela Rago
- Jonny Di Giandomenico
- Francesca Spirito
- Raffaele Porrini
- Marianna De Muro
- Sabrina Crescenzi Leonetti
- Nicoletta Villivà
- Cinzia De Gregoris
- Massimo Breccia
- Enrico Montefusco
- Cristina Santoro
- Giuseppe Cimino
- Ignazio Majolino
- Maria Gabriella Mazzucconi
- Giuliana Alimena
- Alesssandro Andriani
Publication date
January 2014
DOI Publisher
Wiley ISSN
0361-8609 Citation count (estimate)
18Abstract
To identify prognostic factors affecting thrombosis-free survival (TFS) and overall survival (OS), we report the experience of a Regional cooperative group in a real-life cohort of 1,144 patients with essential thrombocythemia (ET) diagnosed from January 1979 to December 2010. There were 107 thrombotic events (9.4%) during follow-up [60 (5.3%) arterial and 47 (4.1%) venous thromboses]. At univariate analysis, risk factors for a shorter TFS were: age >60 years (P 60 years (P 15 × 10(9) /l (P = 0.0370) were independent risk factors. Previous thrombotic events in ET patients are crucial for TFS but their importance seems related not to the occurrence per se but mainly to the interval between the event and the diagnosi
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