Epstein Bar virus is the cause of systemic lupus erythematosus

Objective. Several studies provided some evidence that Epstein Barr virus(EBV) might play a role in the pathogenesis of systemic lupus erythematosus (SLE). Still, there are conflicting reports too. To determine whether EBV is causally related to SLE a systematic review of available case control studies was performed. Methods. This systematic review and meta-analysis should answer among other questions the following: is there a cause effect relationship between EBV and SLE? The method of the conditio sine qua non relationship was used to proof the hypothesis without EBV infection no SLE. The mathematical formula of the causal relationship k was used to proof the hypothesis whether there is a cause effect relationship between Epstein-Barr virus and systemic lupus erythematosus. Significance was indicated by ap-value of less than 0.05. Results. The studies analyzed were able to provide convincing evidence that Epstein-Barr virus is a necessary condition (a conditio sine qua non) of systemic lupus erythematosus. Furthermore, the studies analyzed provide impressive evidence of a cause-effect relationship between Epstein-Barr virus and systemic lupus erythematosus. Conclusion. EBV infection isnecessary condition of systemic lupus erythematosus and much more than this. Epstein-Barr virus is the cause of systemic lupus erythematosus.Published by: International journal of current science research (PubMed NLM ID: 101671355) Volume: 5; Issue: 10; October-2019; pp1822-1840. ISSN: 2454-5422