A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma
OBJECTIVE: The malignancy of neuroblastoma (NB) is strongly connected with MYCN oncogene status. The...
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from u...
NB,3 a solid tumor of early childhood, derives from the embryonicneural crest. In vitro (1) and in v...
A definite association between the transcription of N-myc oncogene and proliferation-related genes, ...
Gene alteration and abnormal expression of cellular oncogenes has been implicated in the causation ...
Neuroblastoma has obvious heterogeneity. It is one of the few undifferentiated malignant tumors that...
Abstract: Twenty-nine previously untreated neuroblastomas were analyzed for DNA content and percenta...
AbstractThe human p73 gene is a homolog of p53, which has been localized to chromosome 1p36 in a reg...
The human p73 gene is a homolog of p53, which has been localized to chromosome 1p36 in a region that...
Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observe...
Neuroblastoma is a highly genetically heterogeneous form of paediatric cancer with clinical behaviou...
Abstract Detectable levels of MAX messenger RNA were found in a set of human neuroblastoma tumors a...
The c-Myc and MYCN oncogenes strongly induce cell proliferation. Although a limited series of cell c...
Detectable levels of MAX messenger RNA were found in a set of human neuroblastoma tumors and establi...
The copy number of the N-myc oncogene provides a prognostic index for neuroblastoma. The mechanism f...
OBJECTIVE: The malignancy of neuroblastoma (NB) is strongly connected with MYCN oncogene status. The...
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from u...
NB,3 a solid tumor of early childhood, derives from the embryonicneural crest. In vitro (1) and in v...
A definite association between the transcription of N-myc oncogene and proliferation-related genes, ...
Gene alteration and abnormal expression of cellular oncogenes has been implicated in the causation ...
Neuroblastoma has obvious heterogeneity. It is one of the few undifferentiated malignant tumors that...
Abstract: Twenty-nine previously untreated neuroblastomas were analyzed for DNA content and percenta...
AbstractThe human p73 gene is a homolog of p53, which has been localized to chromosome 1p36 in a reg...
The human p73 gene is a homolog of p53, which has been localized to chromosome 1p36 in a region that...
Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observe...
Neuroblastoma is a highly genetically heterogeneous form of paediatric cancer with clinical behaviou...
Abstract Detectable levels of MAX messenger RNA were found in a set of human neuroblastoma tumors a...
The c-Myc and MYCN oncogenes strongly induce cell proliferation. Although a limited series of cell c...
Detectable levels of MAX messenger RNA were found in a set of human neuroblastoma tumors and establi...
The copy number of the N-myc oncogene provides a prognostic index for neuroblastoma. The mechanism f...
OBJECTIVE: The malignancy of neuroblastoma (NB) is strongly connected with MYCN oncogene status. The...
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from u...
NB,3 a solid tumor of early childhood, derives from the embryonicneural crest. In vitro (1) and in v...