The effect of moxonidine on atherosclerosis

Background: Atherosclerosis is an inflammatory disease with hypertension as a risk factor. Moxonidine decreases blood pressure and has an anti-inflammatory effect. Aim: To investigate the effect of moxonidine on atherosclerosis: Key methods and results: For the in vivo experiment, twenty male apolipoprotein E-deficient mice were randomized into two groups: the control and moxonidine treatment groups. The mice from the moxonidine treatment group were treated with moxonidine via drinking water (69 mg/L) which equated to a dose of 18 mg/kg body weight per day, whereas the mice from the control group received normal drinking water without moxonidine. All the mice received angiotensin II (1Doctor of Philosoph